التفاصيل البيبلوغرافية
| العنوان: |
Once-weekly semaglutide doubles the five-year risk of nonarteritic anterior ischemic optic neuropathy in a Danish cohort of 424,152 persons with type 2 diabetes |
| المؤلفون: |
Jakob Grauslund, Andreas Abou Taha, Laleh Dehghani Molander, Ryo Kawasaki, Sören Möller, Kurt Højlund, Lonny Stokholm |
| المصدر: |
International Journal of Retina and Vitreous, Vol 10, Iss 1, Pp 1-8 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Ophthalmology |
| مصطلحات موضوعية: |
Cohort study, Nonarteritic anterior ischemic optic neuropathy, Registry based, Semaglutide, Type 2 diabetes, Ophthalmology, RE1-994 |
| الوصف: |
Abstract Background Nonarteritic anterior ischemic optic neuropathy (NAION) is an untreatable condition often causing severe and irreversible visual loss in the affected eye. As it has recently been implied that the use of semaglutide associates with NAION, the aim of the present study was to evaluate this risk prospectively in all persons with type 2 diabetes (T2D) in Denmark. Methods In a five-year longitudinal cohort study, we identified all persons with T2D in Denmark (n = 424,152) between 2018 and 2024. Patients were stratified according to exposure (n = 106,454) or non-exposure (n = 317,698) to once-weekly semaglutide, and incidence rates and hazard ratios (HR) of NAION were estimated in a multivariable Cox proportional hazard regression model. Results At baseline, median age and hemoglobin A1c were 65 years and 50 mmol/mol, and 54·5% were male. During 1,915,120 person-years of observation, 218 persons developed NAION. Semaglutide exposure was associated with a higher incidence rate (0·228 vs. 0·093 per 1000 person-years, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2056-9920 |
| Relation: |
https://doaj.org/toc/2056-9920 |
| DOI: |
10.1186/s40942-024-00620-x |
| URL الوصول: |
https://doaj.org/article/d3bc1a41430c4f6caaaf51b01e581a8c |
| رقم الانضمام: |
edsdoj.3bc1a41430c4f6caaaf51b01e581a8c |
| قاعدة البيانات: |
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