Academic Journal
Autologous hematopoietic stem cell transplantation as a method of immune prevention of type 1 diabetes mellitus: possibilities and prospects
| العنوان: | Autologous hematopoietic stem cell transplantation as a method of immune prevention of type 1 diabetes mellitus: possibilities and prospects |
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| المؤلفون: | M. E. Chernaya, Y. Sh. Khalimov, A. R. Volkova, A. V. Lisker, A. A. Nersesyan, A. D. Orlovskaya, A. Y. Polushin, Y. R. Zalyalov, A. D. Kulagin |
| المصدر: | Сахарный диабет, Vol 27, Iss 3, Pp 277-286 (2024) |
| بيانات النشر: | Endocrinology Research Centre, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | type 1 diabetes, immunotherapy, monoclonal antibodies, high-dose immunosuppressive therapy, autologous transplantation of hematopoietic stem cells, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Type 1 diabetes mellitus (DM) is one of the most common autoimmune disease that is treated with lifelong insulin therapy. Non-target indicators of glycemic control, which are observed in 71% of patients, lead to the formation and progression of diabetes complications, early disability and mortality. In this regard, the search for new approaches to the treatment and prevention of type 1 DM seems to be relevant. Various methods of immunological prophylaxis for the development of type 1 DM have been studied, in particular, the use of monoclonal antibodies. Thus, in November 2022, teplizumab was approved to slow down the clinical progression of the stage of type 1 DM. The prospects for the use of new options for islet cell transplantation are being studied — in June 2023, an allogeneic donor β-cell transplant obtained from the pancreas of donors after death was approved. Another pathogenetically substantiated method for the prevention and treatment of autoimmune diseases is high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation (HDIT-HSCT). HDIT-HSCT demonstrated its effectiveness and cost-effectiveness in various clinical trials. This review provides up-to-date information on modern methods of immunological prophylaxis of type 1 DM. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 2072-0351 2072-0378 |
| Relation: | https://www.dia-endojournals.ru/jour/article/view/13089; https://doaj.org/toc/2072-0351; https://doaj.org/toc/2072-0378 |
| DOI: | 10.14341/DM13089 |
| URL الوصول: | https://doaj.org/article/3b87cf79adce4d5ebc73bf085c139dc1 |
| رقم الانضمام: | edsdoj.3b87cf79adce4d5ebc73bf085c139dc1 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20720351 20720378 |
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| DOI: | 10.14341/DM13089 |