التفاصيل البيبلوغرافية
| العنوان: |
Beneficial immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in Duchenne muscular dystrophy: Results of an open-label, prospective, exploratory case-control clinical study |
| المؤلفون: |
Kadalraja Raghavan, Vidyasagar Devaprasad Dedeepiya, Subramaniam Srinivasan, Subramanian Pushkala, Sudhakar S. Bharatidasan, Nobunao Ikewaki, Masaru Iwasaki, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel J.K. Abraham |
| المصدر: |
IBRO Neuroscience Reports, Vol 15, Iss , Pp 90-99 (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
Duchenne muscular dystrophy, N-163, Beta glucan, Disease modifying agent, Inflammation, Fibrosis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Background: This exploratory case-control study is to evaluate the effects of supplementation of Aureobasidium pullulans-N-163 strain produced 1,3–1,− 6 beta glucan in young patients with Duchenne muscular dystrophy (DMD). Methods: Twenty-seven male subjects aged 5–19 years with DMD were included, nine in the control arm and 18 in the treatment arm to receive N-163 beta glucan along with conventional therapies for 45 days. While performing the analysis, steroid usage was also taken into consideration, those not administered steroids (Steroid -ve) (Control, n = 5; treatment, n = 9), those administered steroids (Steroid +ve) (Control, n = 4; treatment, n = 9). Results: IL-6 showed a significant decrease in the treatment groups, especially the N-163 Steroid -ve group. IL-13 decreased in both treatment groups and TGF-β levels showed a significant decrease in the treatment groups, especially the N-163 Steroid –ve group, (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2667-2421 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2667242123000556; https://doaj.org/toc/2667-2421 |
| DOI: |
10.1016/j.ibneur.2023.06.007 |
| URL الوصول: |
https://doaj.org/article/3b2d112bca03423ab8f1008755450dbb |
| رقم الانضمام: |
edsdoj.3b2d112bca03423ab8f1008755450dbb |
| قاعدة البيانات: |
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