التفاصيل البيبلوغرافية
| العنوان: |
The bispecific B7H3xCD3 antibody CC-3 induces T cell immunity against bone and soft tissue sarcomas |
| المؤلفون: |
Samuel J. Holzmayer, Kai Liebel, Ilona Hagelstein, Helmut R. Salih, Melanie Märklin |
| المصدر: |
Frontiers in Immunology, Vol 15 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
bispecific antibody, B7-H3, CD276, sarcoma, T cell engager, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
Sarcomas are rare and heterogeneous malignancies that are difficult to treat. Approximately 50% of patients diagnosed with sarcoma develop metastatic disease with so far very limited treatment options. The transmembrane protein B7-H3 reportedly is expressed in various malignancies, including different sarcoma subtypes. In several cancer entities B7-H3 expression is associated with poor prognosis. In turn, B7-H3 is considered a promising target for immunotherapeutic approaches. We here report on the preclinical characterization of a B7-H3xCD3 bispecific antibody in an IgG-based format, termed CC-3, for treatment of different sarcoma subtypes. We found B7-H3 to be expressed on all sarcoma cells tested and expression on sarcoma patients correlated with decreased progression-free and overall survival. CC-3 was found to elicit robust T cell responses against multiple sarcoma subtypes, resulting in significant activation, release of cytokines and effector molecules. In addition, CC-3 promoted T cell proliferation and differentiation, resulting in the generation of memory T cell subsets. Finally, CC-3 induced potent target cell lysis in a target cell restricted manner. Based on these results, a clinical trial evaluating CC-3 in soft tissue sarcoma is currently in preparation. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1391954/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2024.1391954 |
| URL الوصول: |
https://doaj.org/article/e3b1784090fa44b59e048df06e322d59 |
| رقم الانضمام: |
edsdoj.3b1784090fa44b59e048df06e322d59 |
| قاعدة البيانات: |
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