Academic Journal
Effects of Melatonin on Cardiac Injury and Inflammatory Biomarkers in Patients Undergoing Coronary Artery Bypass Graft Surgery: a Meta-analysis
| العنوان: | Effects of Melatonin on Cardiac Injury and Inflammatory Biomarkers in Patients Undergoing Coronary Artery Bypass Graft Surgery: a Meta-analysis |
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| المؤلفون: | Melika Farshidianfar, Ali Ardekani, Reza Tabrizi, Kamran B. Lankarani, Erfan Taherifard, Ashkan Abdollahi, Arezou Azizi, Maryam Akbari |
| المصدر: | Cardiology and Therapy, Vol 12, Iss 1, Pp 11-20 (2022) |
| بيانات النشر: | Adis, Springer Healthcare, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Coronary artery bypass, Melatonin, Troponin I, Creatine kinase MB form, C-reactive protein, Meta-analysis, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Abstract Introduction The antiinflammatory and antioxidative effects of melatonin have been established in recent years. Several studies indicate that oxidative stress and inflammation are key drivers of post-coronary artery bypass graft (CABG) surgery complications. In the present study, we aimed to investigate the effects of melatonin on cardiac injury and inflammatory biomarkers in CABG candidates. Methods Embase, Medline/PubMed, Web of Science, Scopus, and the Cochrane library were searched up to 5 June 2022. All randomized controlled trials examining cardiac injury and inflammatory biomarkers of CABG patients who received melatonin were included. The random-effects model was utilized to perform the analysis. Results A total of 947 citations were retrieved through database searches. Finally, five articles (six trials with 342 patients) were included after the screening. Melatonin supplementation led to a significant reduction in cardiac troponin I (CTnI) [weighted mean difference(WMD): −2.28 ng/ml; 95% CI −2.87, −1.69; P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2193-8261 2193-6544 |
| Relation: | https://doaj.org/toc/2193-8261; https://doaj.org/toc/2193-6544 |
| DOI: | 10.1007/s40119-022-00287-1 |
| URL الوصول: | https://doaj.org/article/c3ac3736654f4420b165472553ee1b6a |
| رقم الانضمام: | edsdoj.3ac3736654f4420b165472553ee1b6a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21938261 21936544 |
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| DOI: | 10.1007/s40119-022-00287-1 |