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Occurrence and role of Tph cells in various renal diseases

التفاصيل البيبلوغرافية
العنوان: Occurrence and role of Tph cells in various renal diseases
المؤلفون: Junyi Ren, Kuai Ma, Xiangheng Lu, Haoyu Peng, Jia Wang, Moussa Ide Nasser, Chi Liu
المصدر: Molecular Medicine, Vol 30, Iss 1, Pp 1-12 (2024)
بيانات النشر: BMC, 2024.
سنة النشر: 2024
المجموعة: LCC:Therapeutics. Pharmacology
LCC:Biochemistry
مصطلحات موضوعية: Peripheral helper T cells, T follicular helper T cells, Autoimmune nephropathy, Renal diseases, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436
الوصف: Abstract A new population of peripheral helper T (Tph) cells has been identified and contributed to various autoimmune diseases. Tph cells can secrete interleukin-21 (IL-21), interferon (IFN) and C-X-C motif chemokine ligand 13 (CXCL13) to moderate renal disease. Moreover, Tph cells can congregate in huge numbers and immerse within inflamed tissue. Compared to Tfh cells, Tph cells express high programmed cell death protein 1 (PD-1), major histocompatibility complex II (MHC-II), C-C chemokine receptor 2 (CCR2) and C-C chemokine receptor 5 (CCR5) but often lack expression of the chemokine receptor C-X-C chemokine receptor 5 (CXCR5). They display features distinct from other T cells, which are uniquely poised to promote responses and antibody production of B cells within pathologically inflamed non-lymphoid tissues and a key feature of Tph cells. In this review, we summarize recent findings on the role of Tph cells in chronic kidney disease, acute kidney injury, kidney transplantation and various renal diseases.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1528-3658
Relation: https://doaj.org/toc/1528-3658
DOI: 10.1186/s10020-024-00919-3
URL الوصول: https://doaj.org/article/3a895359dac24c36b070bb9864f9d4f0
رقم الانضمام: edsdoj.3a895359dac24c36b070bb9864f9d4f0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15283658
DOI:10.1186/s10020-024-00919-3