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Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors

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العنوان: Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors
المؤلفون: Ayesa Syenina, Cyril J Jagaraj, Siti AB Aman, Aishwarya Sridharan, Ashley L St John
المصدر: eLife, Vol 4 (2015)
بيانات النشر: eLife Sciences Publications Ltd, 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: dengue virus, vascular leakage, antibodies, mast cell, Fc receptor, Medicine, Science, Biology (General), QH301-705.5
الوصف: Dengue virus (DENV) is the most significant human arboviral pathogen and causes ∼400 million infections in humans each year. In previous work, we observed that mast cells (MC) mediate vascular leakage during DENV infection in mice and that levels of MC activation are correlated with disease severity in human DENV patients (St John et al., 2013b). A major risk factor for developing severe dengue is secondary infection with a heterologous serotype. The dominant theory explaining increased severity during secondary DENV infection is that cross-reactive but non-neutralizing antibodies promote uptake of virus and allow enhanced replication. Here, we define another mechanism, dependent on FcγR-mediated enhanced degranulation responses by MCs. Antibody-dependent mast cell activation constitutes a novel mechanism to explain enhanced vascular leakage during secondary DENV infection.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/05291; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.05291
URL الوصول: https://doaj.org/article/393b72b615524f4986b07ba8b813c930
رقم الانضمام: edsdoj.393b72b615524f4986b07ba8b813c930
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.05291