Academic Journal
Evaluation of seven gene signature for predicting HCV recurrence post-liver transplantation
| العنوان: | Evaluation of seven gene signature for predicting HCV recurrence post-liver transplantation |
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| المؤلفون: | Ghada M. Salum, Mai Abd el Meguid, Tawfeek H. Abelhafez, Eman Medhat, Ashraf O. Abdel Aziz, Reham Dawood |
| المصدر: | Journal of Genetic Engineering and Biotechnology, Vol 19, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | HCV, CRS, Donor steatosis, Recipients, Orthotropic liver transplantation, SNP, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract Background Orthotropic liver transplantation (OLT) offers a therapeutic choice for hepatocellular carcinoma (HCC) patients. The poor outcome of liver transplantation is HCV recurrence. Several genome-wide associated studies (GWAS) have reported many genetic variants to be associated with HCV recurrence. Seven gene polymorphisms formed a cirrhosis risk score (CRS) signature that could be used to distinguish chronic HCV patients at high risk from those at low risk for cirrhosis in non-transplant patients. This study aims to examine the association of CRS score and other clinical parameters with the probability for HCC emergence and/or the rate of HCV recurrence following liver transplantation. Results Seven gene polymorphisms, forming the CRS, were genotyped by real-time PCR using allelic discrimination protocol in 199 end-stage liver disease patients (79 child A, 43 child B, and 77child C), comprising 106 patients who encountered liver transplantation. Recipient CRS scores were correlated with HCV recurrence (HCV-Rec) at the end of the third year after OLT. Around 81% (39) recipients with low steatosis (LS; < 3.5%) donor percentage revealed no HCV recurrence (non-Rec) (p3.5% [OR, 46.07; 95% CI, 1.5–1407.8]. Conclusions Accordingly, the CRS score seems to be less useful to predict HCV recurrence after OLT. ALT and donor steatosis (exceed 3.5%) can significantly promote the HCV recurrence post-OLT. Moreover, the combination of MMF and CNI positively heightens HCV recurrence. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-5920 |
| Relation: | https://doaj.org/toc/2090-5920 |
| DOI: | 10.1186/s43141-021-00266-4 |
| URL الوصول: | https://doaj.org/article/3912f7441c4b4838bbcf21b1c872ebc4 |
| رقم الانضمام: | edsdoj.3912f7441c4b4838bbcf21b1c872ebc4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20905920 |
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| DOI: | 10.1186/s43141-021-00266-4 |