التفاصيل البيبلوغرافية
| العنوان: |
Severe Demyelinating Neuropathy in an Advanced Melanoma Patient Treated with Nivolumab plus Ipilimumab Combined Therapy |
| المؤلفون: |
Yumi Kambayashi, Taku Fujimura, Hiroshi Kuroda, Atsushi Otsuka, Hiroyuki Irie, Setsuya Aiba |
| المصدر: |
Case Reports in Oncology, Vol 13, Iss 1, Pp 474-477 (2020) |
| بيانات النشر: |
Karger Publishers, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
demyelinating peripheral neuropathy, nivolumab plus ipilimumab combined therapy, advanced melanoma, immune-related adverse event, high-dose methylprednisolone monotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Immune checkpoint inhibitors (ICIs) significantly prolong survival in patients with metastatic melanoma but can lead to serious immune-related adverse events. In this report, we described a case of atypical neuropathy caused by nivolumab plus ipilimumab combination therapy before primary tumor resection. In our case, not only demyelinating neuropathy, but also muscle weakness and unilateral facial nerve palsy developed and manifested as severe and diverse symptoms. Moreover, unlike spontaneously developing demyelinating peripheral neuropathy, the present case suggested the therapeutic effects of high-dose methylprednisolone monotherapy for the treatment of ICIs-induced immune-related demyelinating peripheral neuropathy. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-6575 |
| Relation: |
https://www.karger.com/Article/FullText/506976; https://doaj.org/toc/1662-6575 |
| DOI: |
10.1159/000506976 |
| URL الوصول: |
https://doaj.org/article/a38efd331a154b1392db1f612129eb7d |
| رقم الانضمام: |
edsdoj.38efd331a154b1392db1f612129eb7d |
| قاعدة البيانات: |
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