التفاصيل البيبلوغرافية
| العنوان: |
Association between alcohol flushing syndrome and cancer: A systematic review and meta-analysis |
| المؤلفون: |
Wilson Sim, Jason Timothy Pan, Cheryl Wan Xuan Chua, Khi Yung Fong, Sunny H Wong, Bernett Lee, Hazel H Oon |
| المصدر: |
Annals, Academy of Medicine, Singapore, Vol 53, Iss 7, Pp 420-434 (2024) |
| بيانات النشر: |
Academy of Medicine Singapore, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
Medicine |
| الوصف: |
Introduction: Alcohol flushing syndrome (AFS) is experienced by up to 46% of East Asians. This study aimed to review the risk of cancers in AFS patients, elucidate an exposure-response relationship, and understand risk associated with alcohol intake and cancer. Method: An electronic database search of PubMed, Embase, Scopus and Cochrane Library was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Observational studies on AFS’ effects and all cancers risk were included. Studies including patients with existing malignancy were excluded. Dichotomous variables were pooled using the Mantel-Haenszel method with a random effects model. Sensitivity and subgroup analyses were performed. PROSPERO (CRD42023392916) protocol was followed. Results: A total of 18 articles were included in the final analysis with a total of 387,521 participants. AFS was associated with an increased risk of all cancers (odds ratio [OR] 1.19, 95% confidence interval [CI] 1.06–1.34), esophageal squamous cell carcinoma (OR 1.47, 95% CI 1.05–2.05) and gastric adenocarcinoma (OR 1.40, 95% CI 1.14–1.72). Men with AFS exhibited an increased risk of all cancers (OR 1.34, 95% CI 1.13–1.59). However, this was not observed in women. All cancers risk was associated with AFS in those who consumed drink (i.e. consumed alcohol) more than 200 g of pure ethanol/week (OR 1.68, 95% CI 1.20–2.37) but not those who consumed less than 200 g of pure ethanol/week (OR 1.27, 95% CI 0.90–1.79) or non-drinkers (OR 0.99, 95% CI 0.67–1.47). Conclusion: AFS is associated with an increased risk of all cancers, particularly esophageal squamous cell carcinoma and gastric adenocarcinoma. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2972-4066 |
| Relation: |
https://annals.edu.sg/association-between-alcohol-flushing-syndrome-and-cancer-a-systematic-review-and-meta-analysis/; https://doaj.org/toc/2972-4066 |
| DOI: |
10.47102/annals-acadmedsg.2023351 |
| URL الوصول: |
https://doaj.org/article/389f1401f4a84e4481adb80eb07db08d |
| رقم الانضمام: |
edsdoj.389f1401f4a84e4481adb80eb07db08d |
| قاعدة البيانات: |
Directory of Open Access Journals |