التفاصيل البيبلوغرافية
| العنوان: |
Abnormal Expression of Prolyl Oligopeptidase (POP) and Its Catalytic Products Ac-SDKP Contributes to the Ovarian Fibrosis Change in Polycystic Ovary Syndrome (PCOS) Mice |
| المؤلفون: |
Suo Han, Shimeng Wang, Xiang Fan, Mengchi Chen, Xiaojie Wang, Yingtong Huang, Hongdan Zhang, Yinyin Ma, Jing Wang, Chunping Zhang |
| المصدر: |
Biomedicines, Vol 11, Iss 7, p 1927 (2023) |
| بيانات النشر: |
MDPI AG, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
polycystic ovary syndrome (PCOS), prolyl oligopeptidase (POP), N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), fibrosis, TGF-β1, MMP2, Biology (General), QH301-705.5 |
| الوصف: |
Polycystic ovary syndrome (PCOS) is an endocrine disorder and metabolic syndrome. Ovarian fibrosis pathological change in PCOS has gradually attracted people’s attention. In this study, we constructed a PCOS mouse model through the use of dehydroepiandrosterone. Sirius red staining showed that the ovarian tissues in PCOS mice had obvious fibrosis. Prolyl oligopeptidase (POP) is a serine protease and N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is its catalytic product. Studies show that abnormal expression and activity of POP and Ac-SDKP are closely related to tissue fibrosis. It was found that the expression of POP and Ac-SDKP was decreased in the ovaries of PCOS mice. Further studies showed that POP and Ac-SDKP promoted the expression of matrix metalloproteinases 2 (MMP-2) expression and decreased the expression of transforming growth factor beta 1 (TGF-β1) in granulosa cells. Hyperandrogenemia is a typical symptom of PCOS. We found that testosterone induced the low expression of POP and MMP2 and high expression of TGF-β1 in granulosa cells. POP overexpression and Ac-SDKP treatment inhibited the effect of testosterone on TGF-β1 and MMP2 in vitro and inhibited ovarian fibrosis in the PCOS mouse model. In conclusion, PCOS ovarian tissue showed obvious fibrosis. Low expression of POP and Ac-SDKP and changes in fibrotic factors contribute to the ovarian pathological fibrosis induced by androgen. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2227-9059 |
| Relation: |
https://www.mdpi.com/2227-9059/11/7/1927; https://doaj.org/toc/2227-9059 |
| DOI: |
10.3390/biomedicines11071927 |
| URL الوصول: |
https://doaj.org/article/3870dcc53cbb43d7bdcbfb03bc566855 |
| رقم الانضمام: |
edsdoj.3870dcc53cbb43d7bdcbfb03bc566855 |
| قاعدة البيانات: |
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