Academic Journal
Figuring the characteristics of the Delta variant SARS-CoV-2 gene mutations in an Indonesian hospital: a descriptive study
| العنوان: | Figuring the characteristics of the Delta variant SARS-CoV-2 gene mutations in an Indonesian hospital: a descriptive study |
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| المؤلفون: | Phey Liana, Muhammad Agung Maulana, Eny Rahmawati, Rouly Pola Pasaribu, Kemas Yakub Rahadiyanto, Nelda Aprilia Salim, Tungki Pratama Umar |
| المصدر: | Exploration of Medicine, Vol 4, Iss 5, Pp 839-846 (2023) |
| بيانات النشر: | Open Exploration Publishing Inc., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Other systems of medicine |
| مصطلحات موضوعية: | covid-19, genome, mutation, pandemic, Other systems of medicine, RZ201-999 |
| الوصف: | Aim: Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 has undergone several mutations, and ultimately, Indonesia was designated the Asian epicenter of the pandemic in 2021 due to the emergence of Delta variant SARS-CoV-2. Therefore, this study aimed to determine the characteristics of the Delta variant SARS-CoV-2 gene mutations. Methods: This is a cross-sectional descriptive study to determine the mutation characteristics of the Delta variant SARS-CoV-2 with data collected from patients’ medical records and whole genome sequencing (WGS). Results: The forty-nine patients who contracted the Delta variant SARS-CoV-2 were mainly aged 31−45 years and female. Four sublineages were identified, namely AY.23 (69.39%), AY.24 (22.45%), B.1.617.2 (6.12%), and AY.62 (2.04%), with fever and malaise being the most common clinical manifestations (79.60%). Furthermore, the spike (S) protein was most frequently mutated (12 mutations), with mutations in the Delta variant SARS-CoV-2 membrane (M) protein, nucleocapsid (N) protein, open reading frame (ORF), and nonstructural protein (NSP) also identified. Conclusions: The most common Delta variant SARS-CoV-2 sublineage in the current study cohort was AY.23, with the S protein being most frequently mutated. Continuous genomic surveillance is required to contain future outbreaks or infection waves, especially during the COVID-19 pandemic. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2692-3106 38021285 |
| Relation: | https://www.explorationpub.com/Journals/em/Article/1001181; https://doaj.org/toc/2692-3106 |
| DOI: | 10.37349/emed.2023.00181 |
| URL الوصول: | https://doaj.org/article/38021285c2ae4fcfa3951cece5264f48 |
| رقم الانضمام: | edsdoj.38021285c2ae4fcfa3951cece5264f48 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 26923106 38021285 |
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| DOI: | 10.37349/emed.2023.00181 |