Academic Journal
Immunomodulatory differences between mesenchymal stem cells from different oral tissues
| العنوان: | Immunomodulatory differences between mesenchymal stem cells from different oral tissues |
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| المؤلفون: | Chen Cao, Bartosz Maska, Malika A. Malik, Rebecca Tagett, Darnell Kaigler |
| المصدر: | Heliyon, Vol 10, Iss 1, Pp e23317- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Mesenchymal stem cells, Immunoregulation, Differential gene expression, Cytokines, Cell-cell interactions, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Mesenchymal stem cells (MSCs) have recently been identified as having potentially therapeutic immunomodulatory properties. MSCs isolated from different oral tissues have similar morphology and immunophenotypes, however, direct comparisons of their gene expression and immunomodulatory properties have not been conducted. We isolated alveolar bone-derived MSCs (aBMSCs), dental pulp stem cells (DPSCs) and gingiva-derived MSCs (GMSCs) from the same patients and compared their immunophenotypes and transcriptomes. Additionally, we compared their production of soluble immunomodulatory cytokines as well as their immunoregulatory properties in coculture with THP-1 human monocytic cells. RNA sequencing revealed distinct gene expression in DPSCs while aBMSCs and GMSCs had less differentially expressed genes. DPSCs also had significantly less secretion of osteopontin compared to aBMSCs and GMSCs. Finally, DPSCs did not exhibit an immunosuppresive effect on THP-1 cells to the same degree as aBMSCs and GMSCs. These findings demonstrate that MSCs from different oral tissues have distinct transcriptomes and immunoregulatory properties. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023105251; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e23317 |
| URL الوصول: | https://doaj.org/article/37d0ec3632ba49f6adf620de74f0c18e |
| رقم الانضمام: | edsdoj.37d0ec3632ba49f6adf620de74f0c18e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e23317 |