Academic Journal
Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
| العنوان: | Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults |
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| المؤلفون: | Ge Li, Jane B. Shofer, Eric C. Petrie, Chang-En Yu, Charles W. Wilkinson, Dianne P. Figlewicz, Andrew Shutes-David, Jing Zhang, Thomas J. Montine, Murray A. Raskind, Joseph F. Quinn, Douglas R. Galasko, Elaine R. Peskind |
| المصدر: | Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-9 (2017) |
| بيانات النشر: | BMC, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Alzheimer’s disease, Cerebrovascular disease, Cerebrospinal fluid, Biomarkers, Age, Gender, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Abstract Background This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer’s disease (AD) and cerebrovascular injury across the life span of cognitively normal adults. Methods CSF amyloid beta1–42 (Aβ42), phospho-tau-181 (p-tau181), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100. Results CSF total tau and p-tau181 increased with age over the adult life span (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1758-9193 |
| Relation: | http://link.springer.com/article/10.1186/s13195-017-0271-9; https://doaj.org/toc/1758-9193 |
| DOI: | 10.1186/s13195-017-0271-9 |
| URL الوصول: | https://doaj.org/article/37ae6c007eb441d5a1090613eb54784d |
| رقم الانضمام: | edsdoj.37ae6c007eb441d5a1090613eb54784d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17589193 |
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| DOI: | 10.1186/s13195-017-0271-9 |