Academic Journal
Changed functional connectivity at rest in functional illiterates after extensive literacy training
| العنوان: | Changed functional connectivity at rest in functional illiterates after extensive literacy training |
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| المؤلفون: | Bahram Mohammadi, Thomas F. Münte, David M. Cole, Amir Sami, Melanie Boltzmann, Jascha Rüsseler |
| المصدر: | Neurological Research and Practice, Vol 2, Iss 1, Pp 1-15 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Functional connectivity, Functional illiteracy, Independent component analysis, Training intervention, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Abstract Background About 6.2 million adults in Germany cannot read and write properly despite attending school for several years. They are considered to be functional illiterates (FI). Since the ability to read and write is crucial for being employed and socially accepted, we developed a special literacy training to overcome these deficits. Methods In this study, we investigate training-related changes in intrinsic functional connectivity (iFC) at rest in a group of 20 FI and 20 adult normal readers using resting state functional magnetic resonance imaging (rsfMRI). We used independent component analysis (ICA) to define different networks. Results Before training, the between group analysis showed increased iFC in FI in a left-fronto-parietal network (LFPN; anterior insula, medial frontal cortex, lateral and frontal parietal regions) and in the Basal Ganglia network (BGN: thalamus, caudate, putamen, pallidum, amygdala, supplementary motor cortex and cingulate gyrus). Furthermore, the Visual Network-1 (VN1; temporal occipital fusiform gyrus, lateral occipital cortex, occipital pole, lingual gyrus, thalamus) showed decreased iFC in FI. After training the FI group showed reversal of the “hyperconnectivity” in middle frontal gyrus and in the frontal orbital cortex and between supramarginal gyrus and the BGN. Furthermore, functional connectivity increased in FI VN1 (lateral occipital cortex, insular cortex). These changes in connectivity correlated with gains in reading speed and spelling accuracy. Conclusions These findings show that poor reading and writing abilities are associated with abnormalities in iFC in several brain areas subserving cognitive processes important for reading. Intensive literacy training induces changes in the functional connectivity between and within neural networks important for literacy skills. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2524-3489 |
| Relation: | http://link.springer.com/article/10.1186/s42466-020-00058-0; https://doaj.org/toc/2524-3489 |
| DOI: | 10.1186/s42466-020-00058-0 |
| URL الوصول: | https://doaj.org/article/e37aa21468b0418f82aa81fbd88fc97b |
| رقم الانضمام: | edsdoj.37aa21468b0418f82aa81fbd88fc97b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25243489 |
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| DOI: | 10.1186/s42466-020-00058-0 |