التفاصيل البيبلوغرافية
| العنوان: |
Gut microbiome alterations in colitis rats after moxibustion at bilateral Tianshu acupoints |
| المؤلفون: |
Qin Qi, Ya-Nan Liu, Si-Yi Lv, Huan-Gan Wu, Lin-Shuang Zhang, Zhan Cao, Hui-Rong Liu, Xiao-Mei Wang, Lu-Yi Wu |
| المصدر: |
BMC Gastroenterology, Vol 22, Iss 1, Pp 1-14 (2022) |
| بيانات النشر: |
BMC, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: |
Ulcerative colitis, Moxibustion, Gut microbiota, Metagenomic, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: |
Abstract Background The pathogenesis of ulcerative colitis (UC) is closely related to the gut microbiota. Moxibustion has been used to improve the inflammation and gastrointestinal dysfunctions in gastrointestinal disorders such as UC. In this study, we investigated whether moxibustion could improve the gut microbial dysbiosis induced by dextran sulphate sodium. Methods Twenty-five male rats were randomly assigned into five groups. The UC rat model was established by administering DSS solution. The rats in the moxibustion and normal rats with moxibustion groups were treated with moxibustion at Tianshu (bilateral, ST25) points, and the mesalazine group rats were treated with mesalazine once daily for 7 consecutive days. Disease activity index (DAI) and haematoxylin and eosin staining were used to evaluate the effect of moxibustion. Gut microbiota profiling was conducted by metagenomic high throughput sequencing technology. The gut microbiota composition, diversity and function were analyzed and compared using metagenomics methodologies. Results The DAI scores and histopathology scores in the moxibustion and mesalazine groups were significantly decreased compared with the UC group (P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-230X |
| Relation: |
https://doaj.org/toc/1471-230X |
| DOI: |
10.1186/s12876-022-02115-1 |
| URL الوصول: |
https://doaj.org/article/37799117c9e24f0dbb60f37c90ca38c6 |
| رقم الانضمام: |
edsdoj.37799117c9e24f0dbb60f37c90ca38c6 |
| قاعدة البيانات: |
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