Academic Journal
Bioactive Hydrogel Marbles
| العنوان: | Bioactive Hydrogel Marbles |
|---|---|
| المؤلفون: | Álvaro J. Leite, Nuno M. Oliveira, Wenlong Song, João F. Mano |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) |
| بيانات النشر: | Nature Portfolio, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Liquid Marbles, Bioactive Glass Nanoparticles (BGNPs), Bone-like Apatite Layer, Cell Encapsulation, Gelatin Methacrylate, Medicine, Science |
| الوصف: | Abstract Liquid marbles represented a significant advance in the manipulation of fluids as they used particle films to confine liquid drops, creating a robust and durable soft solid. We exploit this technology to engineering a bioactive hydrogel marble (BHM). Specifically, pristine bioactive glass nanoparticles were chemically tuned to produce biocompatible hydrophobic bioactive glass nanoparticles (H-BGNPs) that shielded a gelatin-based bead. The designed BHM shell promoted the growth of a bone-like apatite layer upon immersion in a physiological environment. The fabrication process allowed the efficient incorporation of drugs and cells into the engineered structure. The BHM provided a simultaneously controlled release of distinct encapsulated therapeutic model molecules. Moreover, the BHM sustained cell encapsulation in a 3D environment as demonstrated by an excellent in vitro stability and cytocompatibility. The engineered structures also showed potential to regulate a pre-osteoblastic cell line into osteogenic commitment. Overall, these hierarchical nanostructured and functional marbles revealed a high potential for future applications in bone tissue engineering. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-018-33192-6 |
| URL الوصول: | https://doaj.org/article/36d79bf6c44f4037876c262bf211b24c |
| رقم الانضمام: | edsdoj.36d79bf6c44f4037876c262bf211b24c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
|---|---|
| DOI: | 10.1038/s41598-018-33192-6 |