التفاصيل البيبلوغرافية
| العنوان: |
T cell perturbations persist for at least 6 months following hospitalization for COVID-19 |
| المؤلفون: |
Melissa Govender, Francis R. Hopkins, Robin Göransson, Cecilia Svanberg, Esaki M. Shankar, Maria Hjorth, Åsa Nilsdotter-Augustinsson, Johanna Sjöwall, Sofia Nyström, Marie Larsson |
| المصدر: |
Frontiers in Immunology, Vol 13 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, T cell activation, T cell impairment, T cell subsets, neutralizing antibodies, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
COVID-19 is being extensively studied, and much remains unknown regarding the long-term consequences of the disease on immune cells. The different arms of the immune system are interlinked, with humoral responses and the production of high-affinity antibodies being largely dependent on T cell immunity. Here, we longitudinally explored the effect COVID-19 has on T cell populations and the virus-specific T cells, as well as neutralizing antibody responses, for 6-7 months following hospitalization. The CD8+ TEMRA and exhausted CD57+ CD8+ T cells were markedly affected with elevated levels that lasted long into convalescence. Further, markers associated with T cell activation were upregulated at inclusion, and in the case of CD69+ CD4+ T cells this lasted all through the study duration. The levels of T cells expressing negative immune checkpoint molecules were increased in COVID-19 patients and sustained for a prolonged duration following recovery. Within 2-3 weeks after symptom onset, all COVID-19 patients developed anti-nucleocapsid IgG and spike-neutralizing IgG as well as SARS-CoV-2-specific T cell responses. In addition, we found alterations in follicular T helper (TFH) cell populations, such as enhanced TFH-TH2 following recovery from COVID-19. Our study revealed significant and long-term alterations in T cell populations and key events associated with COVID-19 pathogenesis. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.931039/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.931039 |
| URL الوصول: |
https://doaj.org/article/36d36c5703a047859ea7151466c3c80d |
| رقم الانضمام: |
edsdoj.36d36c5703a047859ea7151466c3c80d |
| قاعدة البيانات: |
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