التفاصيل البيبلوغرافية
| العنوان: |
A canine model of experimental infection with Leishmania (L.) mexicana |
| المؤلفون: |
Julio Vladimir Cruz-Chan, Amarú del Carmen Aguilar-Cetina, Liliana Estefanía Villanueva-Lizama, Pedro Pablo Martínez-Vega, Maria Jesús Ramírez-Sierra, Miguel Enrique Rosado-Vallado, José Leonardo Guillermo-Cordero, Eric Dumonteil |
| المصدر: |
Parasites & Vectors, Vol 7, Iss 1, Pp 1-9 (2014) |
| بيانات النشر: |
BMC, 2014. |
| سنة النشر: |
2014 |
| المجموعة: |
LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: |
Leishmaniasis, Canine model, Experimental infection, Infectious and parasitic diseases, RC109-216 |
| الوصف: |
Abstract Background Cutaneous leishmaniasis is a tropical disease affecting over one million patients annually and Leishmania (L.) mexicana is one of the major etiological agents in the Americas. Here we established the first experimental infection of L. (L.) mexicana in canids. Methods Beagle dogs were infected intradermally with culture-derived L. (L.) mexicana. We followed skin ulcer development, histopathological signs, parasite burden and the immune status of the infected dogs. Results All infected dogs developed uniform oval-craterform ulcers similar to those observed in humans, associated with mixed T helper 1/T helper 2 immune responses. Parasites were detected in the healed lesions 15 weeks post-infection. Higher anti-Leishmania IgG levels correlated with larger lesions and high IgG1/IgG2 ratio was associated with some level of splenomegaly. Conclusions The canine model described in this work will be of use for further understanding of L. (L.) mexicana immunopathogenensis, and for drug and vaccine development. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1756-3305 |
| Relation: |
https://doaj.org/toc/1756-3305 |
| DOI: |
10.1186/1756-3305-7-361 |
| URL الوصول: |
https://doaj.org/article/36be322b4a9b4c8d9aee8d80364a000a |
| رقم الانضمام: |
edsdoj.36be322b4a9b4c8d9aee8d80364a000a |
| قاعدة البيانات: |
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