Academic Journal

Simultaneous Determination of Active Clinical Components of Teicoplanin and Ramoplanin in Environmental Water by LC-MS/MS Coupled With Cascade Elution

التفاصيل البيبلوغرافية
العنوان: Simultaneous Determination of Active Clinical Components of Teicoplanin and Ramoplanin in Environmental Water by LC-MS/MS Coupled With Cascade Elution
المؤلفون: Hui Jin, Cheng Zhao, Yi Yin, Guangming Zheng, Lichun li, Qi Shan, Meiyu Zhang, Linting Wei, Xiaona Shi, Heqing Huang, Wenjing Zhang, Shugui Liu
المصدر: Frontiers in Environmental Science, Vol 9 (2021)
بيانات النشر: Frontiers Media S.A., 2021.
سنة النشر: 2021
المجموعة: LCC:Environmental sciences
مصطلحات موضوعية: teicoplanin, LC-MS/MS, cascade elution, environmental water, ramoplanin, Environmental sciences, GE1-350
الوصف: A simple, sensitive, and simultaneous method was established and validated for the active clinical components of teicoplanin and ramoplanin in environmental water by LC-MS/MS coupled with cascade elution. Moreover, a cascade elution method, which was rapid, solvent-less, and high-extraction efficient was successfully proposed to realize the extraction and purification of seven targets in one step. Under optimized conditions, the method showed excellent linearity with the correlation coefficient (R2) ≥0.998 in the range of 1.0–100.0 ng L−1. Low matrix effects and good recoveries which ranged from 86 to 114% were reached with RSDs lower than 3.0% for most targets. The limits of detection and limit of quantification were 0.1–1.3 and 0.3–4.0 ng L−1, respectively. This method was successfully applied for the determination of teicoplanin and ramoplanin in water samples from the Pearl River and the South China Sea. TA2-2,3 was quantified in only one sample with the concentration of 8.0 ng L−1.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2296-665X
Relation: https://www.frontiersin.org/articles/10.3389/fenvs.2021.785408/full; https://doaj.org/toc/2296-665X
DOI: 10.3389/fenvs.2021.785408
URL الوصول: https://doaj.org/article/36b691f83a05456489ad2dfb8fda8514
رقم الانضمام: edsdoj.36b691f83a05456489ad2dfb8fda8514
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2296665X
DOI:10.3389/fenvs.2021.785408