Academic Journal
Randomized, multicenter, parallel, open, phase 4 study to compare the efficacy and safety of rosuvastatin/amlodipine polypill versus atorvastatin/amlodipine polypill in hypertension patient with dyslipidemia
| العنوان: | Randomized, multicenter, parallel, open, phase 4 study to compare the efficacy and safety of rosuvastatin/amlodipine polypill versus atorvastatin/amlodipine polypill in hypertension patient with dyslipidemia |
|---|---|
| المؤلفون: | Hae Won Jung, Chang‐Yeon Kim, Seung‐Pyo Hong, Han‐Joon Bae, Ji Yong Choi, Jae Kean Ryu, Jin‐bae Lee, Kyoung‐Hoon Lee, Kyoo‐Rok Han, Dong‐Heon Yang, Chang‐Gyu Park, Gheol‐Woong Yu, Moo‐Yong Rhee, Sung‐Ji Park, Min‐Su Hyon, Joon‐Han Shin, Bum‐Kee Hong, Han‐Young Jin, Sung‐Yun Lee, Sang‐Hoon Seol, Sang‐Rok Lee, Song‐Yi Kim, Kwang‐Je Lee, Eun‐Joo Cho, Chang‐Wook Nam, Tae‐Ho Park, Ung Kim, Kee‐Sik Kim |
| المصدر: | The Journal of Clinical Hypertension, Vol 25, Iss 9, Pp 828-844 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | amlodipine, atorvastatin, dyslipidemia, hypertension, rosuvastatin, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Abstract The authors performed this study to investigate the efficacy and safety of a rosuvastatin (RSV)/amlodipine (AML) polypill compared with those of atorvastatin (ATV)/AML polypill. We included 259 patients from 21 institutions in Korea. Patients were randomly assigned to 1 of 3 treatment groups: RSV 10 mg/AML 5 mg, RSV 20 mg/AML 5 mg, or ATV 20 mg /AML 5 mg. The primary endpoint was the efficacy of the RSV 10.20 mg/AML 5 mg via percentage changes in LDL‐C after 8 weeks of treatment, compared with the ATV 20 mg /AML 5 mg. There was a significant difference in the mean percentage change of LDL‐C at 8 weeks between the RSV 10 mg/AML 5 mg and the ATV 20 mg/AML 5 mg (full analysis set [FAS]: −7.08%, 95% CI: −11.79 to −2.38, p = .0034, per‐protocol analysis set [PPS]: −6.97%, 95% CI: −11.76 to −2.19, p = .0046). Also, there was a significant difference in the mean percentage change of LDL‐C at 8 weeks between the RSV 20 mg/AML 5 mg and the ATV 20 mg/AML 5 mg (FAS: −10.13%, 95% CI: −15.41 to −4.84, p = .0002, PPS: −10.96%, 95% CI: −15.98 to −5.93, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1751-7176 1524-6175 |
| Relation: | https://doaj.org/toc/1524-6175; https://doaj.org/toc/1751-7176 |
| DOI: | 10.1111/jch.14715 |
| URL الوصول: | https://doaj.org/article/dcd367a8963148ea91c9d1000d664c1a |
| رقم الانضمام: | edsdoj.367a8963148ea91c9d1000d664c1a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17517176 15246175 |
|---|---|
| DOI: | 10.1111/jch.14715 |