Academic Journal

The PREVENT study to evaluate the effectiveness and acceptability of a community-based intervention to prevent childhood tuberculosis in Lesotho: study protocol for a cluster randomized controlled trial

التفاصيل البيبلوغرافية
العنوان: The PREVENT study to evaluate the effectiveness and acceptability of a community-based intervention to prevent childhood tuberculosis in Lesotho: study protocol for a cluster randomized controlled trial
المؤلفون: Yael Hirsch-Moverman, Andrea A. Howard, Koen Frederix, Limakatso Lebelo, Anneke Hesseling, Sharon Nachman, Joanne E. Mantell, Tsepang Lekhela, Llang Bridget Maama, Wafaa M. El-Sadr
المصدر: Trials, Vol 18, Iss 1, Pp 1-11 (2017)
بيانات النشر: BMC, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: Ttuberculosis prevention, Child contact management, IPT initiation, IPT completion, Cluster-randomized trial, Mixed-methods, Medicine (General), R5-920
الوصف: Abstract Background Effective, evidence-based interventions to prevent childhood tuberculosis (TB) in high TB/HIV-burden, resource-limited settings are urgently needed. There is limited implementation of evidence-based contact management strategies, including isoniazid preventive therapy (IPT), for child contacts of TB cases in Lesotho. Methods/design This mixed-methods implementation science study utilizes a two-arm cluster-randomized trial design with randomization at the health facility level. The study aims to evaluate the effectiveness and acceptability of a combination community-based intervention (CBI) versus standard of care (SOC) for the management of child TB contacts. The study includes three phases: (I) exploratory phase; (II) intervention implementation and testing phase; (III) post-intervention explanatory phase. Healthcare provider interviews to inform intervention refinement (phase I) were completed in December 2015. In phase II, 10 health facilities were randomized to deliver the CBI or SOC, with stratification by facility type (i.e., hospital vs. health center). CBI holistically addresses the complex provider-related, patient-related, and caregiver-related barriers to prevention of childhood TB through nurse training and mentorship; health education for caregivers and patients by village health workers; adherence support using text messaging and village health workers; and multidisciplinary team meetings, where programmatic data are reviewed and challenges and solutions are discussed. SOC sites follow country guidelines for child TB contact management. Routine TB program data will be abstracted for all adult TB cases newly registered during the study period and their child contacts from TB registers and cards. The anticipated sample size is 1080 child contacts. Primary outcomes are yield (number) of child contacts, including children
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1745-6215
Relation: http://link.springer.com/article/10.1186/s13063-017-2184-0; https://doaj.org/toc/1745-6215
DOI: 10.1186/s13063-017-2184-0
URL الوصول: https://doaj.org/article/d35ffe47de91475d9bd1cf1d8aa952ea
رقم الانضمام: edsdoj.35ffe47de91475d9bd1cf1d8aa952ea
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17456215
DOI:10.1186/s13063-017-2184-0