التفاصيل البيبلوغرافية
| العنوان: |
Shorter telomere length in COPD cases secondary to biomass-burning smoke exposure |
| المؤلفون: |
Angélica Domínguez-de-Barros, Gloria Pérez-Rubio, Ingrid Fricke-Galindo, Alejandra Ramírez-Venegas, Malena Gajate-Arenas, Rafael Hernández-Zenteno, Salvador García-Carmona, Robinson Robles-Hernández, María E. Ramírez-Díaz, Filiberto Cruz-Vicente, María L. Martínez-Gómez, Jacob Lorenzo-Morales, Ramcés Falfán-Valencia, Elizabeth Córdoba-Lanús |
| المصدر: |
Respiratory Research, Vol 26, Iss 1, Pp 1-8 (2025) |
| بيانات النشر: |
BMC, 2025. |
| سنة النشر: |
2025 |
| المجموعة: |
LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: |
Biomass smoke, COPD, Pulmonary function, Telomere length, Diseases of the respiratory system, RC705-779 |
| الوصف: |
Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction and destruction of lung tissue, primarily attributed to tobacco smoking. However, other factors like biomass-burning smoke (BS) exposure are also implicated. COPD has been described as an accelerated aging disease, and telomere length is a biomarker of aging. Methods This study examined telomere length in 189 Mexican individuals, from which 93 developed COPD secondary to BS exposure (BE-COPD); the rest of the participants were exposed to BS but did not develop the disease. Lung function parameters were measured by spirometry, and relative telomere length (rTL) from peripheral blood DNA was determined using multiplex qPCR. Results Results showed rTL to inversely correlate with age (R2=-0.207, p = 0.006) and with the hours-a-day of BS exposure (R2=-0.297, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1465-993X |
| Relation: |
https://doaj.org/toc/1465-993X |
| DOI: |
10.1186/s12931-024-03074-9 |
| URL الوصول: |
https://doaj.org/article/35e187034f3c439a8827b06f71c51ee0 |
| رقم الانضمام: |
edsdoj.35e187034f3c439a8827b06f71c51ee0 |
| قاعدة البيانات: |
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