التفاصيل البيبلوغرافية
| العنوان: |
The impact of comorbidities, neutrophil-to-lymphocyte ratio, and drug toxicities on quality of life in lung cancer patients receiving EGFR-TKI therapy |
| المؤلفون: |
Jung-Yueh Chen, Sheng-Kai Liang, Tzu-Yi Chuang, Chia-Yu Chu, Chia-Hung Tu, Yu-Jo Yeh, Yu-Feng Wei, Kuan-Yu Chen |
| المصدر: |
Journal of the Formosan Medical Association, Vol 123, Iss 2, Pp 198-207 (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
Adverse events, Comorbidity, Epidermal growth factor receptor tyrosine kinase inhibitor, Non-small cell lung cancer, Quality of life, Neutrophil-to-lymphocyte ratio, Medicine (General), R5-920 |
| الوصف: |
Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are used as the standard first-line treatment for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC). However, the impact of comorbidities and treatment toxicities on quality of life (QoL) was seldom investigated. Objective: We aimed to investigate the association of comorbidities, adverse events (AEs), and QoL in treatment-naïve advanced NSCLC patients receiving EGFR-TKI treatments. Methods: This multi-center prospective observational study was conducted to evaluate QoL and AEs at baseline, the 2nd, 4th, 12th, and 24th week. Clinical characteristics, comorbidities, and pre-treatment laboratory data were recorded. QoL was assessed by using the summary score of the EORTC QLQ-C30 and the dermatology life quality index. The impact of comorbidities, neutrophil-to-lymphocyte ratio (NLR), and AEs on QoL was analyzed by generalized estimating equations. Results: A total of 121 patients were enrolled. Diarrhea (p = 0.033), anorexia (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0929-6646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0929664623002917; https://doaj.org/toc/0929-6646 |
| DOI: |
10.1016/j.jfma.2023.07.017 |
| URL الوصول: |
https://doaj.org/article/35cd2d64adf249559b93739c6530ae0d |
| رقم الانضمام: |
edsdoj.35cd2d64adf249559b93739c6530ae0d |
| قاعدة البيانات: |
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