Academic Journal
Antiglycation Effect of Jabuticaba (Plinia cauliflora) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats
| العنوان: | Antiglycation Effect of Jabuticaba (Plinia cauliflora) and Its Potential Role in Delaying Cataract Formation in Streptozotocin-Induced Diabetic Rats |
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| المؤلفون: | Arif Yanuar Ridwan, Yuki Shimozu, Nikesh Narang, Takashi Kometani, Yusuke Yamashita, Young-Il Kim |
| المصدر: | Nutraceuticals, Vol 4, Iss 3, Pp 363-372 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | Jabuticaba, glycation, ellagitannins, cataract, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Jabuticaba fruit (Plinia cauliflora) is widely consumed in various forms such as juice, jam, wine, and liquors; however, its potential therapeutic effects on diabetic complications remain inadequately explored. We aimed to investigate the potential antiglycation activity of Jabuticaba, identify the active compounds through bioassay-guided fractionation, and assess its effects on cataract formation in a Streptozotocin-induced diabetic type 1 rat model. Through bioassay-guided fractionation, we identified gallic acid (IC50: 24.7 µg/mL), protocatechuic acid (IC50: 1.22 µg/mL), and an ellagitannin, Repandinin B (IC50: 0.55 µg/mL), as active compounds contributing to antiglycation effects. In the animal study, the addition of Jabuticaba juice extract to the drinking water at a concentration of 0.5% (w/v) for 12 weeks demonstrated an amelioration in cataract progression. These results suggest that Jabuticaba has high antiglycation effects leading to the delaying of cataract formation in type 1 diabetes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1661-3821 |
| Relation: | https://www.mdpi.com/1661-3821/4/3/21; https://doaj.org/toc/1661-3821 |
| DOI: | 10.3390/nutraceuticals4030021 |
| URL الوصول: | https://doaj.org/article/e35c754c635444478a568da994074682 |
| رقم الانضمام: | edsdoj.35c754c635444478a568da994074682 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16613821 |
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| DOI: | 10.3390/nutraceuticals4030021 |