Academic Journal
Use of oral antineoplastic in special situations in a third level hospital: real life results
| العنوان: | Use of oral antineoplastic in special situations in a third level hospital: real life results |
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| المؤلفون: | José Miguel Ferrari-Piquero, Pedro Pablo Rodriguez-Quesada, Carmen Garcia-Muñoz |
| المصدر: | Farmacia Hospitalaria, Vol 42, Iss 01, Pp 5-9 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Pharmacy and materia medica LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Oral antineoplastic, Off-label use, Compassionate use, Oncology, Drug prescriptions, Pharmacy and materia medica, RS1-441, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Objective: To analyse the effectiveness and safety of oral antineoplastic drugs (ANEOs) that are authorized in special situations in a third-level hospital and to compare the results obtained with the clinical evidence used for this authorization. Method: Descriptive observational and retrospective study. We included all adult patients who started treatment with ANEO in special situations during the year 2016. We collected demographic, treatment-related and clinical variables (overall survival (OS), progression-free survival (PFS)). Adverse reactions and detected interactions were collected. An unadjusted comparison was made between the results of the available evidence and those of the study patients. Results: 34 patients were treated, 50% were men, the median age was 58 years (38-80) and they presented ECOG 1 in 64.7%. Most of the treated patients were diagnosed with advanced colorectal cancer, treated with trifluridine-tipiracil, followed by palbociclib in breast cancer, obtaining results similar to those of the evidence. The median PFS was 2.8 months (95% CI 0.8- 4.8) and the 8-month SG (95% CI 3.4-12.5) for all patients. 26% of patients required dose reduction because of treatment toxicity. We found 13 interactions, which affected 15 patients, only two of category X. Conclusions: The effectiveness of ANEO in special situations in our center is similar to that of available evidence. The impact on survival is low and adverse effects are common. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian |
| تدمد: | 1130-6343 2171-8695 |
| Relation: | http://www.aulamedica.es/fh/pdf/10856.pdf; https://doaj.org/toc/1130-6343; https://doaj.org/toc/2171-8695 |
| DOI: | 10.7399/fh.10856 |
| URL الوصول: | https://doaj.org/article/3574fb80a3c44e71af96653a352cb9cd |
| رقم الانضمام: | edsdoj.3574fb80a3c44e71af96653a352cb9cd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11306343 21718695 |
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| DOI: | 10.7399/fh.10856 |