التفاصيل البيبلوغرافية
| العنوان: |
CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout |
| المؤلفون: |
Savita Devi, Mohanalaxmi Indramohan, Elisabeth Jäger, Jessica Carriere, Lan H. Chu, Lucia de Almeida, David R. Greaves, Christian Stehlik, Andrea Dorfleutner |
| المصدر: |
Cell Reports, Vol 42, Iss 3, Pp 112265- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
CP: Immunology, CP: Molecular biology, Biology (General), QH301-705.5 |
| الوصف: |
Summary: Inflammatory responses are crucial for controlling infections and initiating tissue repair. However, excessive and uncontrolled inflammation causes inflammatory disease. Processing and release of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18 depend on caspase-1 activation within inflammasomes. Assembly of inflammasomes is initiated upon activation of cytosolic pattern recognition receptors (PRRs), followed by sequential polymerization of pyrin domain (PYD)-containing and caspase recruitment domain (CARD)-containing proteins mediated by homotypic PYD and CARD interactions. Small PYD- or CARD-only proteins (POPs and COPs, respectively) evolved in higher primates to target these crucial interactions to limit inflammation. Here, we show the ability of COPs to regulate inflammasome activation by modulating homotypic CARD-CARD interactions in vitro and in vivo. CARD16, CARD17, and CARD18 displace crucial CARD interactions between caspase-1 proteins through competitive binding and ameliorate uric acid crystal-mediated NLRP3 inflammasome activation and inflammatory disease. COPs therefore represent an important family of inflammasome regulators and ameliorate inflammatory disease. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124723002760; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2023.112265 |
| URL الوصول: |
https://doaj.org/article/356acb21046a4a7d9e2a97a5f2b82fc3 |
| رقم الانضمام: |
edsdoj.356acb21046a4a7d9e2a97a5f2b82fc3 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder