التفاصيل البيبلوغرافية
| العنوان: |
CAR-T Therapy for T-lineage Leukemia: Progress, Dilemmas, and Way Forward |
| المؤلفون: |
Yajing HAN, Liping ZHAO, Kaiting TANG, Qing NIU, Jing PAN, Xiaoming FENG |
| المصدر: |
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 8, Pp 648-654 (2024) |
| بيانات النشر: |
Magazine House of Cancer Research on Prevention and Treatment, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
cellular immunotherapy, chimeric antigen receptor t-cell therapy, t-cell acute lymphoblastic leukemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Tumor immunotherapy occupies a pivotal position in the field of hematological malignancies. Chimeric antigen receptor (CAR) T-cell therapy has established a new therapeutic pattern for hematological immunotherapy and achieved satisfactory clinical results in the treatment of B-lineage hematological malignancies. However, CAR T-cell therapy has some limitations in the treatment of T-cell acute lymphoblastic leukemia because of the presence of CAR T-cell fratricide, tumor cell contamination, T-cell aplasia, and other clinically relevant problems. Therefore, the current major challenge is overcoming the existing bottlenecks to optimize CAR-T therapy and improve its efficacy against T-ALL while improving the prognosis of patients. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
Chinese |
| تدمد: |
1000-8578 |
| Relation: |
https://doaj.org/toc/1000-8578 |
| DOI: |
10.3971/j.issn.1000-8578.2024.24.0301 |
| URL الوصول: |
https://doaj.org/article/356ab3a80d3b45df983e66a0bbd94215 |
| رقم الانضمام: |
edsdoj.356ab3a80d3b45df983e66a0bbd94215 |
| قاعدة البيانات: |
Directory of Open Access Journals |