Academic Journal
The effect of cardiac resynchronization therapy on arterial stiffness and central hemodynamic parameters
| العنوان: | The effect of cardiac resynchronization therapy on arterial stiffness and central hemodynamic parameters |
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| المؤلفون: | Metin Coksevim, Murat Akcay, Serkan Yuksel, Mustafa Yenercag, Bugra Cerik, Omer Gedikli, Okan Gulel, Mahmut Sahin |
| المصدر: | Journal of Arrhythmia, Vol 36, Iss 3, Pp 498-507 (2020) |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | cardiac response, cardiac resynchronization therapy, congestive heart failure, hemodynamics parameters, pulse wave velocity, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Abstract Introduction Cardiac resynchronization therapy (CRT) is a device‐based method of treatment which decreases morbidity and mortality in heart failure with reduced ejection fraction (HFrEF). This study was aimed to investigate the effects of CRT on hemodynamic and arterial stiffness parameters evaluated by noninvasive method, and determine whether there is a correlation between the changes after CRT in these parameters and the clinical response to CRT or not. Methods The study included 46 patients with HFrEF who were planned to undergo CRT implantation. Before the CRT implantation, clinical and demographic data were recorded from all patients. Hemodynamic and arterial stiffness parameters were measured oscillometrically by an arteriograph before CRT implantation. The patients were re‐evaluated minimum three months after CRT; the above‐mentioned parameters were measured again and compared to the pre‐CRT period. Results Compared to the period before CRT, mean systolic blood pressure (SBP) (116.8 ± 19.1 mm Hg vs 127.7 ± 20.9 mm Hg, P = .005), central SBP (cSBP) (106.2 ± 17.3 mm Hg vs 116.8 ± 18.7 mm Hg, P = .015), cardiac output (CO) (4.6 ± 0.8 lt/min vs 5.1 ± 0.8 lt/min, P = .002), stroke volume (65.6 ± 16.3 mL vs 72.0 ± 14.9 mL), and pulse wave velocity (PWV) (10 ± 1.6 m/sec vs 10.4 ± 1.8 m/sec, P = .004) increased significantly in post‐CRT period. In addition, the same parameters were significantly increased post‐CRT period in patients with clinical response. However, there was not any similar increase in nonresponder patients. Conclusion This study demonstrated that SBP, CO, and PWV increased significantly after CRT. The modest increases in these parameters were observed to be associated with positive clinical outcomes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1883-2148 1880-4276 |
| Relation: | https://doaj.org/toc/1880-4276; https://doaj.org/toc/1883-2148 |
| DOI: | 10.1002/joa3.12331 |
| URL الوصول: | https://doaj.org/article/35676c485b614028a346d0ad1950d219 |
| رقم الانضمام: | edsdoj.35676c485b614028a346d0ad1950d219 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18832148 18804276 |
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| DOI: | 10.1002/joa3.12331 |