التفاصيل البيبلوغرافية
| العنوان: |
Eyes on amyloidosis: microvascular retinal dysfunction in cardiac amyloidosis |
| المؤلفون: |
Emanuel Zampiccoli, Jens Barthelmes, Leonie Kreysing, Matthias P. Nägele, Delia Nebunu, Thomas Haider, Arnold vonEckardstein, Bernhard Gerber, Rahel Schwotzer, Frank Ruschitzka, Isabella Sudano, Andreas J. Flammer |
| المصدر: |
ESC Heart Failure, Vol 9, Iss 2, Pp 1186-1194 (2022) |
| بيانات النشر: |
Wiley, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
Cardiac amyloidosis, Retinal vessel analysis, Vascular dysfunction, Endothelium, Heart failure, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Abstract Aims Cardiac involvement in systemic amyloidosis is a marker of particularly poor prognosis. Cardiac amyloidosis (CA) is characterized by extracellular amyloid deposits inducing heart failure and symptoms of cardiac microvascular disease. While amyloid deposition is most common in the myocardium but also seen in pericardium and endocardium, atria, and vasculature, the role of (micro‐)vascular dysfunction in CA pathophysiology remains still elusive. Because vascular function is associated with cardiovascular risk and severity of heart failure and represents a potential therapeutic target in CA, the present study investigated retinal vascular function, flow‐mediated dilatation (FMD), and pulse‐wave analysis and velocity (PWA/PWV) in patients with CA. Methods and results Flicker‐induced arterial dilatation (FIDa) was measured using dynamic retinal vessel analysis additionally to FMD and PWA/PWV. Thirty‐three patients with CA [age 67 years [interquartile range, IQR, 62, 74], 14 with amyloid light‐chain (AL) and 19 with transthyretin (ATTR) amyloidosis] were prospectively included in this cross‐sectional, observational study and 70 healthy individuals (age 53 years [IQR 39, 67]) served as control. Potential confounders were balanced using entropy balancing propensity score analysis [inverse probability weighting (IPW)]. FIDa was reduced in CA patients (1.52 ± 1.73% vs. 3.09 ± 1.96%, P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.13792 |
| URL الوصول: |
https://doaj.org/article/3513defe2cf94899aa7eb9aaef36af6b |
| رقم الانضمام: |
edsdoj.3513defe2cf94899aa7eb9aaef36af6b |
| قاعدة البيانات: |
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