Academic Journal
Mechanobiology in Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity
| العنوان: | Mechanobiology in Metabolic Dysfunction-Associated Steatotic Liver Disease and Obesity |
|---|---|
| المؤلفون: | Emily L. Rudolph, LiKang Chin |
| المصدر: | Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7134-7146 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | mechanobiology, adipocyte biology, hepatocyte biology, intracellular vimentin, extracellular vimentin, Biology (General), QH301-705.5 |
| الوصف: | With the ongoing obesity epidemic, the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is expected to rise and necessitates a greater understanding of how the disease proceeds from benign excess lipid in hepatocytes to liver fibrosis and eventually to liver cancer. MASLD is caused, at least in part, by hepatocytes’ storage of free fatty acids (FAs) that dysfunctional adipocytes are no longer able to store, and therefore, MASLD is a disease that involves both the liver and adipose tissues. The disease progression is not only facilitated by biochemical signals, but also by mechanical cues such as the increase in stiffness often seen with fibrotic fatty livers. The change in stiffness and accumulation of excess lipid droplets impact the ability of a cell to mechanosense and mechanotranduce, which perpetuates the disease. A mechanosensitive protein that is largely unexplored and could serve as a potential therapeutic target is the intermediate filament vimentin. In this review, we briefly summarize the recent research on hepatocyte and adipocyte mechanobiology and provide a synopsis of studies on the varied, and sometimes contradictory, roles of vimentin. This review is intended to benefit and encourage future studies on hepatocyte and adipocyte mechanobiology in the context of MASLD and obesity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/46/7/425; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb46070425 |
| URL الوصول: | https://doaj.org/article/350c11dc060541d6a734dcdbe593f071 |
| رقم الانضمام: | edsdoj.350c11dc060541d6a734dcdbe593f071 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
|---|---|
| DOI: | 10.3390/cimb46070425 |