التفاصيل البيبلوغرافية
| العنوان: |
Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons |
| المؤلفون: |
Nicola B. Mercuri, Mauro Federici, Francesca Romana Rizzo, Lorenzo Maugeri, Sebastian L. D’Addario, Rossella Ventura, Nicola Berretta |
| المصدر: |
Frontiers in Cellular Neuroscience, Vol 15 (2021) |
| بيانات النشر: |
Frontiers Media S.A., 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
dopamine, LTD, striatum, cholinergic interneurons, metabotropic glutamate receptors, amperometry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
The cellular mechanisms regulating dopamine (DA) release in the striatum have attracted much interest in recent years. By in vitro amperometric recordings in mouse striatal slices, we show that a brief (5 min) exposure to the metabotropic glutamate receptor agonist DHPG (50 μM) induces a profound depression of synaptic DA release, lasting over 1 h from DHPG washout. This long-term depression is sensitive to glycine, which preferentially inhibits local cholinergic interneurons, as well as to drugs acting on nicotinic acetylcholine receptors and to the pharmacological depletion of released acetylcholine. The same DHPG treatment induces a parallel long-lasting enhancement in the tonic firing of presumed striatal cholinergic interneurons, measured with multi-electrode array recordings. When DHPG is bilaterally infused in vivo in the mouse striatum, treated mice display an anxiety-like behavior. Our results demonstrate that metabotropic glutamate receptors stimulation gives rise to a prolonged depression of the striatal dopaminergic transmission, through a sustained enhancement of released acetylcholine, due to the parallel long-lasting potentiation of striatal cholinergic interneurons firing. This plastic interplay between dopamine, acetylcholine, and glutamate in the dorsal striatum may be involved in anxiety-like behavior typical of several neuropsychiatric disorders. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-5102 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fncel.2021.798464/full; https://doaj.org/toc/1662-5102 |
| DOI: |
10.3389/fncel.2021.798464 |
| URL الوصول: |
https://doaj.org/article/34bbf5a0412348b482487d602f9dba65 |
| رقم الانضمام: |
edsdoj.34bbf5a0412348b482487d602f9dba65 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder