Academic Journal
Prognostic factors of a lower CD4/CD8 ratio in long term viral suppression HIV infected children.
| العنوان: | Prognostic factors of a lower CD4/CD8 ratio in long term viral suppression HIV infected children. |
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| المؤلفون: | Sara Guillén, Luis Prieto, Santiago Jiménez de Ory, María Isabel González-Tomé, Pablo Rojo, María Luisa Navarro, María José Mellado, Luis Escosa, Talía Sainz, Laura Francisco, María Ángeles Muñoz-Fernández, José Tomás Ramos, CoRISpe (Cohorte Nacional de VIH pediátrica de la RED RIS) |
| المصدر: | PLoS ONE, Vol 14, Iss 8, p e0220552 (2019) |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | BackgroundCombination antiretroviral therapy (cART) is associated with marked immune reconstitution. Although a long term viral suppression is achievable, not all children however, attain complete immunological recovery due to persistent immune activation. We use CD4/CD8 ratio like a marker of immune reconstitution.MethodsPerinatal HIV-infected children who underwent a first-line cART, achieved viral suppression in the first year and maintained it for more than 5 years, with no viral rebound were included. Logistic models were applied to estimate the prognostic factors, clinical characteristics at cART start, of a lower CD4/CD8 ratio at the last visit.Results146 HIV-infected children were included: 77% Caucasian, 45% male and 28% CDC C. Median age at cART initiation was 2.3 years (IQR: 0.5-6.2). 42 (30%) children received mono-dual therapy previously to cART. Time of undetectable viral load was 9.5 years (IQR: 7.8, 12.5). 33% of the children not achieved CD4/CD8 ratio >1. Univariate analysis showed an association between CD4/CD8 ConclusionsCD4/CD8 >1 was not achieved in 33% of the children. Lower CD4 nadir and previous exposure to suboptimal therapy, before initiating cART, are factors showing independently association with a worse immune recovery (CD4/CD8 < 1). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0220552 |
| URL الوصول: | https://doaj.org/article/345549b0b4d94994a4c2d2723ad8d9d4 |
| رقم الانضمام: | edsdoj.345549b0b4d94994a4c2d2723ad8d9d4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0220552 |