التفاصيل البيبلوغرافية
| العنوان: |
Hetero-Type Benzannulation Leading to Substituted Benzothio-Phenes |
| المؤلفون: |
Taro Kono, Ryosuke Sasaki, Hideki Goto, Masatoshi Kakuno, Yoo Tanabe |
| المصدر: |
Molecules, Vol 26, Iss 22, p 7008 (2021) |
| بيانات النشر: |
MDPI AG, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
thiophene, benzothiophene, benzannulation, gem-dichlorocyclopropane, Suzuki–Miyaura cross-coupling, hydroxylation, Organic chemistry, QD241-441 |
| الوصف: |
TiCl4 (or SnCl4)-promoted hetero-type benzannulation reactions using various (2,2-dichlorocyclopropyl)(thiophen-2-yl)methanols proceeded smoothly to produce uniquely substituted 4-chlorobenzothiophenes (five examples). The present approach involves the first distinctive thiophene formation from thiophene cores, in contrast to traditional methods of thiophene formation from benzene cores. The stereocongested (less reactive) Cl position in the obtained 4-chlorobenzothiophenes functioned successfully as the partners of three cross-coupling reactions: (i) a Suzuki–Miyaura cross-couplings using Pd(OAc)2/SPhos/K3PO4 catalysis (seven examples; 63–91%), (ii) a hydroxylation using KOH/Pd(dba)2/tBu-XPhos catalysis (85%), and (iii) a borylation using a B2(pin)2/Pd(dba)2/XPhos/NaOAc catalysis-provided 4-(pin)B-benzothiophene (58%). |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/26/22/7008; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules26227008 |
| URL الوصول: |
https://doaj.org/article/34479747e113498aab0d24246d7fb9fd |
| رقم الانضمام: |
edsdoj.34479747e113498aab0d24246d7fb9fd |
| قاعدة البيانات: |
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