التفاصيل البيبلوغرافية
| العنوان: |
Humoral and cellular responses to spike of δ SARS-CoV-2 variant in vaccinated patients with immune-mediated inflammatory diseases |
| المؤلفون: |
Linda Petrone, Andrea Picchianti-Diamanti, Gian Domenico Sebastiani, Alessandra Aiello, Bruno Laganà, Gilda Cuzzi, Valentina Vanini, Gina Gualano, Alba Grifoni, Mario Ferraioli, Concetta Castilletti, Silvia Meschi, Francesco Vaia, Emanuele Nicastri, Alessandro Sette, Delia Goletti |
| المصدر: |
International Journal of Infectious Diseases, Vol 121, Iss , Pp 24-30 (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: |
IMID, COVID-19, vaccine, immune response, T- cell response, Infectious and parasitic diseases, RC109-216 |
| الوصف: |
Objectives: We assessed vaccination-induced antibody and cellular responses against spike from the ancestral strain and from the delta (δ) SARS-CoV-2 variant in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy in comparison with immunocompetent subjects. Methods: We enrolled patients with IMID and immunocompetent subjects who completed the vaccination schedule within 4–6 months from the first dose. The interferon (IFN)-γ-response to spike peptides that were derived from the ancestral and the δ SARS-CoV-2 were measured by ELISA. Anti-Receptor Binding Domain IgG antibodies were also evaluated. Results: We enrolled 43 patients with IMID and nine immunocompetent subjects. No significant differences were found after comparing the specific immune response (IFN-γ) between patients with IMID and immunocompetent subjects to the ancestral (p = 0.36) or δ peptide pool (p = 0.51). Nevertheless, IFN-γ-specific responses to the ancestral or to the δ pools were reduced in subjects taking CTLA4-IgG or TNF-α inhibitors compared with subjects treated with IL-6 inhibitors or Disease Modifying Anti-Rheumatic Drugs. Regarding the antibody response, no significant differences were observed between patients with IMID and immunocompetent individuals. Conclusions: Cellular responses to δ SARS-CoV-2 variant remain largely intact in patients with IMID. However, the magnitude of these responses is dependent on the specific IMID immunosuppressive regimen. Serological response was also similar between the IMID and control groups. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971222002296; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2022.04.027 |
| URL الوصول: |
https://doaj.org/article/33f59fafc10a4b9ba711de1864bbb5bb |
| رقم الانضمام: |
edsdoj.33f59fafc10a4b9ba711de1864bbb5bb |
| قاعدة البيانات: |
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