التفاصيل البيبلوغرافية
| العنوان: |
Decidualized Endometrial Stromal Cells Promote Mitochondrial Beta-Oxidation to Produce the Octanoic Acid Required for Implantation |
| المؤلفون: |
Yumi Mizuno, Shunsuke Tamaru, Hideno Tochigi, Tomomi Sato, Miyuko Kishi, Akira Ohtake, Osamu Ishihara, Takeshi Kajihara |
| المصدر: |
Biomolecules, Vol 14, Iss 8, p 1014 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
decidualization, octanoic acid, mitochondrial beta-oxidation, embryo implantation, Microbiology, QR1-502 |
| الوصف: |
Decidualization denotes the morphological and biological differentiating process of human endometrial stromal cells (HESCs). Fatty acid pathways are critical for endometrial decidualization. However, the participation of fatty acids as an energy source and their role in endometrial decidualization have received little attention. To identify fatty acids and clarify their role in decidualization, we comprehensively evaluated free fatty acid profiles using liquid chromatography/Fourier transform mass spectrometry (LC/FT-MS). LC/FT-MS analysis detected 26 kinds of fatty acids in the culture medium of decidualized or un-decidualized HESCs. Only the production of octanoic acid, which is an essential energy source for embryonic development, was increased upon decidualization. The expressions of genes related to octanoic acid metabolism including ACADL, ACADM, and ACADS; genes encoding proteins catalyzing the first step of mitochondrial fatty acid beta-oxidation; and ACSL5 and ACSM5; genes encoding fatty acid synthesis proteins were significantly altered upon decidualization. These results suggest that decidualization promotes lipid metabolism, implying that decidualized HESCs require energy metabolism of the mitochondria in embryo implantation. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2218-273X |
| Relation: |
https://www.mdpi.com/2218-273X/14/8/1014; https://doaj.org/toc/2218-273X |
| DOI: |
10.3390/biom14081014 |
| URL الوصول: |
https://doaj.org/article/ac33e75c4bf84b388e65cdfe7af4ddac |
| رقم الانضمام: |
edsdoj.33e75c4bf84b388e65cdfe7af4ddac |
| قاعدة البيانات: |
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