التفاصيل البيبلوغرافية
| العنوان: |
Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders |
| المؤلفون: |
Adrian Mor, Anna Tankiewicz-Kwedlo, Marianna Ciwun, Janina Lewkowicz, Dariusz Pawlak |
| المصدر: |
Cells, Vol 13, Iss 15, p 1259 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Cytology |
| مصطلحات موضوعية: |
tryptophan, kynurenine pathway, kynurenine, indoleamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, kynurenine 3-monooxygenase, Cytology, QH573-671 |
| الوصف: |
This review discusses the potential of targeting the kynurenine pathway (KP) in the treatment of inflammatory diseases. The KP, responsible for the catabolism of the amino acid tryptophan (TRP), produces metabolites that regulate various physiological processes, including inflammation, cell cycle, and neurotransmission. These metabolites, although necessary to maintain immune balance, may accumulate excessively during inflammation, leading to systemic disorders. Key KP enzymes such as indoleamine 2,3-dioxygenase 1 (IDO1), indoleamine 2,3-dioxygenase 2 (IDO2), tryptophan 2,3-dioxygenase (TDO), and kynurenine 3-monooxygenase (KMO) have been considered promising therapeutic targets. It was highlighted that both inhibition and activation of these enzymes may be beneficial, depending on the specific inflammatory disorder. Several inflammatory conditions, including autoimmune diseases, for which modulation of KP activity holds therapeutic promise, have been described in detail. Preclinical studies suggest that this modulation may be an effective treatment strategy for diseases for which treatment options are currently limited. Taken together, this review highlights the importance of further research on the clinical application of KP enzyme modulation in the development of new therapeutic strategies for inflammatory diseases. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/13/15/1259; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells13151259 |
| URL الوصول: |
https://doaj.org/article/ed33ca8b5bdb421abee0a73d3590b929 |
| رقم الانضمام: |
edsdoj.33ca8b5bdb421abee0a73d3590b929 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder