Academic Journal
Preclinical deposition of pathological prion protein in muscle of experimentally infected primates.
| العنوان: | Preclinical deposition of pathological prion protein in muscle of experimentally infected primates. |
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| المؤلفون: | Susanne Krasemann, Melanie Neumann, Markus Geissen, Walter Bodemer, Franz-Josef Kaup, Walter Schulz-Schaeffer, Nathalie Morel, Adriano Aguzzi, Markus Glatzel |
| المصدر: | PLoS ONE, Vol 5, Iss 11, p e13906 (2010) |
| بيانات النشر: | Public Library of Science (PLoS), 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Prion diseases are transmissible fatal neurodegenerative disorders affecting humans and animals. A central step in disease progression is the accumulation of a misfolded form (PrP(Sc)) of the host encoded prion protein (PrP(C)) in neuronal and non-neuronal tissues. The involvement of peripheral tissues in preclinical states increases the risk of accidental transmission. On the other hand, detection of PrP(Sc) in non-neuronal easy-accessible compartments such as muscle may offer a novel diagnostic tool. Primate models have proven invaluable to investigate prion diseases. We have studied the deposition of PrP(Sc) in muscle and central nervous system of rhesus monkeys challenged with sporadic Creutzfeldt-Jakob disease (sCJD), variant CJD (vCJD) and bovine spongiform encephalopathy (BSE) in preclinical and clinical stage using biochemical and morphological methods. Here, we show the preclinical presence of PrP(Sc) in muscle and central nervous system of rhesus monkeys experimentally infected with vCJD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC2978702?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0013906 |
| URL الوصول: | https://doaj.org/article/33a0f364ffc345b790419a0d2179982a |
| رقم الانضمام: | edsdoj.33a0f364ffc345b790419a0d2179982a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0013906 |