Academic Journal
Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction
| العنوان: | Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction |
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| المؤلفون: | Julien Guiot, Makon-Sébastien Njock, Béatrice André, Fanny Gester, Monique Henket, Dominique de Seny, Catherine Moermans, Michel G. Malaise, Renaud Louis |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Systemic sclerosis (SSc) is a rare connective tissue disease associated with rapid evolving interstitial lung disease (ILD), driving its mortality. Specific biomarkers associated with the progression of this lung disease are highly needed. We aimed to identify specific biomarkers of SSc-ILD to predict the evolution of the disease. For this, we compared prospectively serum levels of several biomarkers associated with lung fibrosis in SSc patients (n = 102), among which SSc-no ILD (n = 63) and SSc-ILD (n = 39), compared to healthy subjects (HS) (n = 39). We also performed a longitudinal study in a subgroup of 28 patients analyzing biomarkers variations and pulmonary function tests over a period of 2 years. Serum level of IGFBP-2 was significantly increased in SSc patients compared to HS, and negatively correlated with pulmonary function (assessed by carbon monoxide transfer coefficient (KCO)) (r = − 0.29, p 105 ng/ml was associated with a poor outcome (KCO |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-021-90333-0 |
| URL الوصول: | https://doaj.org/article/332d152eea1a43e2b6806c3da08770b0 |
| رقم الانضمام: | edsdoj.332d152eea1a43e2b6806c3da08770b0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-90333-0 |