Academic Journal
Nepeta Dschuparensis Bornm Extract Moderates COX-2 and IL-1β Proteins in a Rat Model of Cerebral Ischemia
| العنوان: | Nepeta Dschuparensis Bornm Extract Moderates COX-2 and IL-1β Proteins in a Rat Model of Cerebral Ischemia |
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| المؤلفون: | Alireza Mousavi Nia, Taj Pari Kalantaripour, Mohsen Basiri, Farzaneh Vafaee, Majid Asadi-Shekaari, Azam Eslami, Fatemeh Darvish Zadeh |
| المصدر: | Iranian Journal of Medical Sciences, Vol 42, Iss 2, Pp 179-186 (2017) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Nepeta, Hypoxia-Ischemia, Brain antioxidants, Cyclooxygenase 2, Interleukin-1beta, Medicine (General), R5-920 |
| الوصف: | Background: Nepeta dschuparensis Bornm (NP) is used as a medicinal herb in Iran. In traditional medicine, this herb is extensively employed for curing ailments such as cardiovascular diseases. NP has antioxidant and anti-inflammatory properties. This project examined the effects of the NP extract on cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β) protein levels and its efficacy in neuroprotection in a cerebral ischemia-reperfusion model. Methods: Twenty-six male rats were randomly divided into 3 groups: 1) sham (n=6): no middle cerebral artery occlusion (MCAO) procedure, 2) control (n=10): MCAO procedure and treatment with normal saline, and 3) NP extract (n=10): MCAO procedure and treatment with the NP extract (20 mg/kg, i.p.) at the beginning of reperfusion. To examine the injury caused by cerebral ischemia, we measured motor coordination and the infarct area using the rotarod test and triphenyl tetrazolium chloride staining, respectively. IL-1β and COX-2 protein levels, as inflammatory markers, were measured by immunoblotting assay. The statistical analyses were performed using SPSS, version 16, and the data are expressed as means±SEMs. Statistical difference was evaluated using the one-way ANOVA, followed by the post hoc LSD test (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0253-0716 1735-3688 |
| Relation: | http://ijms.sums.ac.ir/index.php/IJMS/article/view/2540; https://doaj.org/toc/0253-0716; https://doaj.org/toc/1735-3688 |
| URL الوصول: | https://doaj.org/article/32f5fe30d00f4c278974d86a35c80bc0 |
| رقم الانضمام: | edsdoj.32f5fe30d00f4c278974d86a35c80bc0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02530716 17353688 |
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