التفاصيل البيبلوغرافية
| العنوان: |
Role of DegQ in differential stability of flagellin subunits in Vibrio vulnificus |
| المؤلفون: |
You-Chul Jung, Mi-Ae Lee, Han-Shin Kim, Kyu-Ho Lee |
| المصدر: |
npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-14 (2021) |
| بيانات النشر: |
Nature Portfolio, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Microbial ecology |
| مصطلحات موضوعية: |
Microbial ecology, QR100-130 |
| الوصف: |
Abstract Biofilm formation of Vibrio vulnificus is initiated by adherence of flagellated cells to surfaces, and then flagellum-driven motility is not necessary during biofilm maturation. Once matured biofilms are constructed, cells become flagellated and swim to disperse from biofilms. As a consequence, timely regulations of the flagellar components’ expression are crucial to complete a biofilm life-cycle. In this study, we demonstrated that flagellins’ production is regulated in a biofilm stage-specific manner, via activities of a protease DegQ and a chaperone FlaJ. Among four flagellin subunits for V. vulnificus filament, FlaC had the highest affinities to hook-associated proteins, and is critical for maturating flagellum, showed the least susceptibility to DegQ due to the presence of methionine residues in its DegQ-sensitive domains, ND1 and CD0. Therefore, differential regulation by DegQ and FlaJ controls the cytoplasmic stability of flagellins, which further determines the motility-dependent, stage-specific development of biofilms. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2055-5008 |
| Relation: |
https://doaj.org/toc/2055-5008 |
| DOI: |
10.1038/s41522-021-00206-7 |
| URL الوصول: |
https://doaj.org/article/328a6a59f60b4c339e985e22a6baf1d3 |
| رقم الانضمام: |
edsdoj.328a6a59f60b4c339e985e22a6baf1d3 |
| قاعدة البيانات: |
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