التفاصيل البيبلوغرافية
| العنوان: |
Comparative Pathogenesis, Genomics and Phylogeography of Mousepox |
| المؤلفون: |
Carla Mavian, Alberto López-Bueno, Rocío Martín, Andreas Nitsche, Antonio Alcamí |
| المصدر: |
Viruses, Vol 13, Iss 6, p 1146 (2021) |
| بيانات النشر: |
MDPI AG, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
mousepox, poxvirus pathogenesis, genome sequence, virulence, A-type inclusion bodies, Microbiology, QR1-502 |
| الوصف: |
Ectromelia virus (ECTV), the causative agent of mousepox, has threatened laboratory mouse colonies worldwide for almost a century. Mousepox has been valuable for the understanding of poxvirus pathogenesis and immune evasion. Here, we have monitored in parallel the pathogenesis of nine ECTVs in BALB/cJ mice and report the full-length genome sequence of eight novel ECTV isolates or strains, including the first ECTV isolated from a field mouse, ECTV-MouKre. This approach allowed us to identify several genes, absent in strains attenuated through serial passages in culture, that may play a role in virulence and a set of putative genes that may be involved in enhancing viral growth in vitro. We identified a putative strong inhibitor of the host inflammatory response in ECTV-MouKre, an isolate that did not cause local foot swelling and developed a moderate virulence. Most of the ECTVs, except ECTV-Hampstead, encode a truncated version of the P4c protein that impairs the recruitment of virions into the A-type inclusion bodies, and our data suggest that P4c may play a role in viral dissemination and transmission. This is the first comprehensive report that sheds light into the phylogenetic and geographic relationship of the worldwide outbreak dynamics for the ECTV species. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1999-4915 |
| Relation: |
https://www.mdpi.com/1999-4915/13/6/1146; https://doaj.org/toc/1999-4915 |
| DOI: |
10.3390/v13061146 |
| URL الوصول: |
https://doaj.org/article/3141def5a16f4780b2dd49e4c6967c54 |
| رقم الانضمام: |
edsdoj.3141def5a16f4780b2dd49e4c6967c54 |
| قاعدة البيانات: |
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