Academic Journal
Síntese e atividade citotóxica de alguns azido-ciclopaladados estabilizados com ligantes bifosfínicos Synthesis and cytotoxicity of some cyclometallated palladium (II) complexes containing coordinated azide and diphosphines
| العنوان: | Síntese e atividade citotóxica de alguns azido-ciclopaladados estabilizados com ligantes bifosfínicos Synthesis and cytotoxicity of some cyclometallated palladium (II) complexes containing coordinated azide and diphosphines |
|---|---|
| المؤلفون: | Antonio Carlos Fávero Caires, Eduardo T. Almeida, Antonio E. Mauro, Jefferson P. Hemerly, Sandro R. Valentini |
| المصدر: | Química Nova, Vol 22, Iss 3, Pp 329-334 (1999) |
| بيانات النشر: | Sociedade Brasileira de Química, 1999. |
| سنة النشر: | 1999 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | azido-cyclopalladated compounds, antitumour agents, palladium (II) complexes, Chemistry, QD1-999 |
| الوصف: | Some cyclopalladated compounds containing the azido group ligand and the (C-N) ring of N,N-dimethylbenzylamine have been prepared by bridge opening reactions of dimmer azide complex precursor with some diphosphines in different stoichiometric quantities. The neutral or ionic, mono or binuclear complexes synthesized were characterized by elemental analyses, I. R. spectroscopy and NMR techniques. The series of complexes was screened for cytotoxicity against a panel three human tumour cells lines(C6,Hep-2,HeLa). All complexes were found to be cytotoxic (IC50) at µM concentrations while one complex having the coordination bond N-Pd ruptured also displayed some differential cytotoxicity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian Portuguese |
| تدمد: | 0100-4042 1678-7064 46179089 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421999000300008; https://doaj.org/toc/0100-4042; https://doaj.org/toc/1678-7064 |
| DOI: | 10.1590/S0100-40421999000300008 |
| URL الوصول: | https://doaj.org/article/30ad4078262d46179089ae17e62123be |
| رقم الانضمام: | edsdoj.30ad4078262d46179089ae17e62123be |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01004042 16787064 46179089 |
|---|---|
| DOI: | 10.1590/S0100-40421999000300008 |