Academic Journal
Evaluation of the stability of hydrocortisone sodium succinate in solutions for parenteral use by a validated HPLC-UV method
| العنوان: | Evaluation of the stability of hydrocortisone sodium succinate in solutions for parenteral use by a validated HPLC-UV method |
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| المؤلفون: | Katja Mihovec, Žane Temova Rakuša, Enikő Éva Gaál, Robert Roškar |
| المصدر: | Acta Chimica Slovenica, Vol 69, Iss 4, Pp 796-802 (2022) |
| بيانات النشر: | Slovenian Chemical Society, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | forced degradation study, in-use stability, infusion, injection, shelf life after opening, solu-cortef., Chemistry, QD1-999 |
| الوصف: | This study aimed to determine the in-use stability (t95%) of hydrocortisone sodium succinate (HSS) infusion solutions and provide evidence-based guidelines on their usability. HSS infusion solutions were prepared and stored as recommended by the manufacturer and under common conditions in our hospital. The effects of HSS concentration (1 and 4 mg/mL), solvent (isotonic saline and glucose), temperature (ambient and 30°C), and light on its stability were evaluated using a validated stability-indicating HPLC-UV method. HSS degradation followed first-order kinetics. No significant difference in its stability was observed between the two evaluated concentrations, solvents and light exposure (t95% between 25 and 30 h). Elevated temperature (30°C) affected HSS stability and significantly reduced the t95% (4.6-6.3 h). HSS infusion solutions are physically and chemically stable (˂5% degradation) for at least 6 h if stored below 30°C. The in-use stability may be extended up to 24 h if stored below 24°C. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1318-0207 1580-3155 |
| Relation: | https://journals.matheo.si/index.php/ACSi/article/view/7539; https://doaj.org/toc/1318-0207; https://doaj.org/toc/1580-3155 |
| DOI: | 10.17344/acsi.2022.7539 |
| URL الوصول: | https://doaj.org/article/30a5da60d89c4527b0668635d209992f |
| رقم الانضمام: | edsdoj.30a5da60d89c4527b0668635d209992f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13180207 15803155 |
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| DOI: | 10.17344/acsi.2022.7539 |