التفاصيل البيبلوغرافية
| العنوان: |
Safety pharmacology of human endogenous retrovirus-enveloped baculoviral DNA vaccines against SARS-CoV-2 in Sprague-Dawley rats and beagle dogs |
| المؤلفون: |
Sang-Jin Park, Joung‐Wook Seo, Kang-Hyun Han, Byoung-Seok Lee, Chanyeong Lee, Bong Young Kim, Kyong-Cheol Ko, Yong-Bum Kim |
| المصدر: |
Vaccine: X, Vol 20, Iss , Pp 100545- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
SARS-CoV-2, Baculovirus, Viral vector vaccine, Safety pharmacology, COVID-19, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
The coronavirus disease 2019 (COVID-19) emerged as a major global health crisis, posing significant health, economic, and social challenges. Vaccine development has been a crucial response to the severe-acute-respiratory-syndrome-related coronavirus-2 pandemic owing to the critical role of immunization in controlling infectious diseases, leading to the expedited development of several effective vaccines. Although mRNA platform-based COVID-19 vaccines authorized under emergency-use authorization have been administered globally, concerns regarding the vaccines have increased owing to the occurrence of various side effects. The present study aimed to evaluate the safety of a non-replicating recombinant baculovirus expressing the human endogenous retrovirus envelope gene (AcHERV) vaccine encoding SARS-CoV-2 antigens. Owing to the limited number of existing safety pharmacology studies on AcHERV as a viral vector vaccine, we conducted neurobehavior (Modified Irwin’s Test), body temperature, and respiratory function studies in rats and cardiovascular system studies in male beagle dogs, which were administered the AcHERV-COVID-19 vaccine using telemetry. The safety assessment revealed no significant toxicological alterations. However, in rats, both sexes administered with the AcHERV-COVID-19 vaccine exhibited a temporary increase in body temperature, which normalized or showed signs of recovery. In conclusion, AcHERV-COVID-19 demonstrates a sufficient safety profile that supports its potential evaluation in future clinical trials. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2590-1362 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2590136224001189; https://doaj.org/toc/2590-1362 |
| DOI: |
10.1016/j.jvacx.2024.100545 |
| URL الوصول: |
https://doaj.org/article/30a2d4449301445f83a040adb42f0cea |
| رقم الانضمام: |
edsdoj.30a2d4449301445f83a040adb42f0cea |
| قاعدة البيانات: |
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