التفاصيل البيبلوغرافية
| العنوان: |
Construction of a tumor immune infiltration macrophage signature for predicting prognosis and immunotherapy response in liver cancer |
| المؤلفون: |
Anmin Huang, Bei Lv, Yunjie Zhang, Junhui Yang, Jie Li, Chengjun Li, Zhijie Yu, Jinglin Xia |
| المصدر: |
Frontiers in Molecular Biosciences, Vol 9 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
macrophage, tumor microenvironment, immune infiltration, prognosis, immunotherapy response, Biology (General), QH301-705.5 |
| الوصف: |
Liver cancer is an extraordinarily heterogeneous malignant disease. The tumor microenvironment (TME) and tumor-associated macrophages (TAMs) are the major drivers of liver cancer initiation and progression. It is critical to have a better understanding of the complicated interactions between liver cancer and the immune system for the development of cancer immunotherapy. Based on the gene expression profiles of tumor immune infiltration cells (TIICs), upregulated genes in TAMs and downregulated genes in other types of immune cells were identified as macrophage-specific genes (MSG). In this study, we combined MSG, immune subtypes, and clinical information on liver cancer to develop a tumor immune infiltration macrophage signature (TIMSig). A four-gene signature (S100A9, SLC22A15, TRIM54, and PPARGC1A) was identified as the TAM-related prognostic genes for liver cancer, independent of multiple clinicopathological parameters. Survival analyses showed that patients with low TIMSig had a superior survival rate than those with high TIMSig. Additionally, clinical immunotherapy response and TIMSig was observed as highly relevant. In addition, TIMSig could predict the response to chemotherapy. Collectively, the TIMSig could be a potential tool for risk-stratification, clinical decision making, treatment planning, and oncology immunotherapeutic drug development. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-889X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmolb.2022.983840/full; https://doaj.org/toc/2296-889X |
| DOI: |
10.3389/fmolb.2022.983840 |
| URL الوصول: |
https://doaj.org/article/e2fc067c9d6543b6827cf51cda1c5212 |
| رقم الانضمام: |
edsdoj.2fc067c9d6543b6827cf51cda1c5212 |
| قاعدة البيانات: |
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