Academic Journal
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance
| العنوان: | The metabolic and physiologic impairments underlying long COVID associated exercise intolerance |
|---|---|
| المؤلفون: | Brooks P. Leitner, Phillip Joseph, Andres Figueroa Quast, Maria Alejandra Ramirez, Paul M. Heerdt, Jose G. Villalobos, Inderjit Singh |
| المصدر: | Pulmonary Circulation, Vol 14, Iss 4, Pp n/a-n/a (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | invasive CPET, long COVID, metabolomic, PASC, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779 |
| الوصف: | Abstract Data from invasive CPET (iCPET) revealed long COVID patients have impaired systemic oxygen extraction (EO2), suggesting impaired mitochondrial ATP production. However, it remains uncertain whether the initial severity of SARS‐CoV‐2 infection has implications on EO2 and exercise capacity (VO2) nor has there been assessment of anerobic ATP generation in long COVID patients. iCPET was performed on 47 long COVID patients (i.e., full cohort; n = 8 with severe SARS‐CoV‐2 infection). In a subset of patients (i.e., metabolomic cohort; n = 26) metabolomics on venous and arterial blood samples during iCPET was performed. In the full cohort, long COVID patients exhibited reduced peak EO2 with reduced peak VO2 (90 ± 17% predicted) relative to cardiac output (118 ± 23% predicted). Peak VO2 [88% predicted (IQR 81% ‐ 108%) vs. 70% predicted (IQR 64% ‐ 89%); p = 0.02] and EO2 [0.59(IQR 0.53–0.62) vs. 0.53(IQR 0.50–0.48); p = 0.01) were lower in severe versus mild infection. In the metabolomic cohort, 12 metabolites were significantly consumed, and 41 metabolites were significantly released (p‐values |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-8940 58813470 |
| Relation: | https://doaj.org/toc/2045-8940 |
| DOI: | 10.1002/pul2.70009 |
| URL الوصول: | https://doaj.org/article/2f588134701940be8528c742bfd1d499 |
| رقم الانضمام: | edsdoj.2f588134701940be8528c742bfd1d499 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20458940 58813470 |
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| DOI: | 10.1002/pul2.70009 |