Academic Journal
Contrast-enhanced near-infrared photoacoustic microscopy and optical coherence tomography imaging of rat fundus
| العنوان: | Contrast-enhanced near-infrared photoacoustic microscopy and optical coherence tomography imaging of rat fundus |
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| المؤلفون: | Du Fengxian, Niu Chen, Zeng Silue, Chen Jingqin, Liu Chengbo, Dai Cuixia |
| المصدر: | Nanophotonics, Vol 13, Iss 19, Pp 3631-3646 (2024) |
| بيانات النشر: | De Gruyter, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Physics |
| مصطلحات موضوعية: | optical coherence tomography, photoacoustic microscopy, contrast agents, Physics, QC1-999 |
| الوصف: | In this paper, we design a multimodal visible/near-infrared photoacoustic microscopy and optical coherence tomography (VIS/NIR-PAM-OCT) system for imaging both retina and retinal pigment epithelium (RPE)/choroid complex layer. F127 and DSPE-PEG-cRGD encapsulated IR-1048 nanoparticles (FINPs) exhibiting absorption peak up to 1,064 nm were utilized as contrast agents to enhance NIR-PAM for in vivo imaging of fundus tissues. The fundus structure and vessels are clearly visualized by the multimodal imaging, and their parameters were quantitatively analyzed. NIR-PAM and OCT imaging of fundus were time-serially monitored over 60 min following the intravenous injection of FINPs into rats. The results indicated a 134 % increase in image signals in PAM at 1 min, along with an 8.23 % intensity enhancement in OCT. Moreover, laser-induced choroidal neovascularization (CNV) was specifically detected and accurately quantified using VIS/NIR-PAM-OCT. Lastly, FINPs demonstrated excellent biocompatibility in hematology analysis and pathology testing. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2192-8614 23315431 |
| Relation: | https://doaj.org/toc/2192-8614 |
| DOI: | 10.1515/nanoph-2023-0872 |
| URL الوصول: | https://doaj.org/article/cca2e4f2331543148d40c7c116bc7102 |
| رقم الانضمام: | edsdoj.2e4f2331543148d40c7c116bc7102 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21928614 23315431 |
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| DOI: | 10.1515/nanoph-2023-0872 |