التفاصيل البيبلوغرافية
| العنوان: |
Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study |
| المؤلفون: |
Weidong Xie, Haojie Jiang, Yao Chen, Zhaojie Yu, Yaoyu Song, Huanhao Zhang, Sen Li, Shaoliang Han, Naxin Liu |
| المصدر: |
Frontiers in Genetics, Vol 15 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Genetics |
| مصطلحات موضوعية: |
systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), inflammatory bowel disease (IBD), type 1 diabetes(T1D), Mendelian randomization(MR), Genetics, QH426-470 |
| الوصف: |
BackgroundPrevious studies have suggested an association between Type 1 diabetes (T1D) and autoimmune diseases (AIDs), but the causal relationship remains unclear. Therefore, this study utilizes publicly available Genome-Wide Association Studies (GWAS) databases and employs a two-sample Mendelian Randomization (MR) approach to explore the causal relationships between T1D and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD).MethodsSummary GWAS data for T1D, SLE, RA, and IBD were downloaded from open GWAS databases and the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). We employed a series of methods to select instrumental variables closely related to T1D. To enhance the reliability of our conclusions, we applied multiple robust analytical methods, with the inverse variance weighted (IVW) method as the primary approach. Validation and meta-analysis were conducted using the FinnGen consortium. Additionally, we assessed heterogeneity, pleiotropy, and sensitivity to ensure the robustness of our conclusions.ResultsA potential causal association was found between T1D and SLE (OR = 1.37, 95% CI = 1.26 – 1.49, P < 0.001), which was further confirmed by meta-analysis. Similarly, a potential causal association was found between T1D and RA (OR = 1.32, 95% CI = 1.17 – 1.50, P < 0.001), and this was also confirmed by meta-analysis. Although the association between T1D and IBD showed P < 0.05, the leave-one-out test did not pass, and further meta-analysis indicated no significant statistical association between them.ConclusionOur study reveals the relationships between T1D and three clinically common autoimmune diseases (SLE, RA, and IBD). This research supplements previous studies and provides a reference for future clinical work. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-8021 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fgene.2024.1335839/full; https://doaj.org/toc/1664-8021 |
| DOI: |
10.3389/fgene.2024.1335839 |
| URL الوصول: |
https://doaj.org/article/2e2c6e010e0e40c59b3dc4454d06fb26 |
| رقم الانضمام: |
edsdoj.2e2c6e010e0e40c59b3dc4454d06fb26 |
| قاعدة البيانات: |
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