Academic Journal
Significant Associations of lncRNA H19 Genotypes with Susceptibility to Childhood Leukemia in Taiwan
| العنوان: | Significant Associations of lncRNA H19 Genotypes with Susceptibility to Childhood Leukemia in Taiwan |
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| المؤلفون: | Jen-Sheng Pei, Chao-Chun Chen, Wen-Shin Chang, Yun-Chi Wang, Jaw-Chyun Chen, Yu-Chen Hsiau, Pei-Chen Hsu, Yuan-Nian Hsu, Chia-Wen Tsai, Da-Tian Bau |
| المصدر: | Pharmaceuticals, Vol 14, Iss 3, p 235 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | lncRNA, H19, SNP, childhood leukemia, genetic susceptibility, Taiwan, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | The purpose of our study was to investigate whether genetic variations in lncRNA H19 were associated with susceptibility to childhood leukemia. Two hundred and sixty-six childhood leukemia patients and 266 healthy controls were enrolled in Taiwan, and two single nucleotide polymorphisms (SNPs), rs2839698 and rs217727, in H19 were genotyped and analyzed. There was a significant difference in the genotypic distribution of rs2839698 between patients and healthy controls (p = 0.0277). Compared to the wild-type CC genotype, the heterozygous variant CT and homozygous variant TT genotypes were associated with significantly increased risks of childhood leukemia with an adjusted odd ratio (OR) of 1.46 (95% confidence interval (CI), 1.08–2.14, p = 0.0429) and 1.94 (95%CI, 1.15–3.31, p = 0.0169), respectively (pfor tread = 0.0277). The difference in allelic frequencies between childhood leukemia patients and controls was also significant (T versus C, adjusted OR = 1.53, 95%CI, 1.13–1.79, p = 0.0077). There were no significant differences in the genotypic and allelic distributions of rs217727 between cases and controls. Interestingly, the average level of H19 rs2839698 was statistically significantly higher for patients with CT and TT genotypes than from those with the CC genotype (p < 0.0001). Our results indicate that H19 SNP rs2839698, but not rs217727, may serve as a novel susceptibility marker for childhood leukemia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 02523434 |
| Relation: | https://www.mdpi.com/1424-8247/14/3/235; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph14030235 |
| URL الوصول: | https://doaj.org/article/2cfbccd02523434280ad47983b5067cb |
| رقم الانضمام: | edsdoj.2cfbccd02523434280ad47983b5067cb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 02523434 |
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| DOI: | 10.3390/ph14030235 |